美国国立卫生研究院资助的外科研究和学术成果模式。

Patterns of National Institutes of Health Grant Funding to Surgical Research and Scholarly Productivity in the United States.

机构信息

Michael and Marian Ilitch Department of Surgery, Wayne State University School of Medicine, Detroit Medical Center, Detroit, MI.

Department of Surgery, North Florida Regional Medical Center, University of Central Florida College of Medicine, Gainesville, FL.

出版信息

Ann Surg. 2020 Oct;272(4):539-546. doi: 10.1097/SLA.0000000000004206.

DOI:10.1097/SLA.0000000000004206

PMID:32740237

Abstract

OBJECTIVE

The aim of this study was to assess the contemporary trends in National Institutes of Health (NIH) grants awarded to surgical investigators, including potential disparities.

BACKGROUND

The NIH remains the primary public funding source for surgical research in the United States; however, the patterns for grants and grantees are poorly understood.

METHODS

NIH RePORTER was queried for new grants (R01, -03, -21) awarded to Departments of Surgery (DoS). Principal investigators' (PIs) data were extracted from publicly available information from their institutions' websites and/or professional social media accounts.

RESULTS

The NIH awarded 1101 new grants (total: $389,006,782; median: $313,030) between 2008 and 2018. Funding to DoS has doubled in the last 10 years ($22,983,500-2008 to $49,446,076-2018). Midwest/Southeast institutions and surgical oncologists accounted for majority of the grants (31.9% and 24.5%, respectively). Only 24.7% of the projects were led by female PIs, who were predominantly nonphysician PhD scientists (52% vs 37.7% PhD-only male PIs; P = 0.002). During this time, there was a significant increase from 12.4% to 31.7% in grants awarded to PIs with >15 years of experience. These grants were associated with 8215 publications; however, only 13.2% were published in high-impact journals (impact factor ≥10). 4.4% of the grants resulted in patents, and these were associated with higher award amounts ($345,801 vs $311,350; P = 0.030). On multivariate analysis, combined MD/PhD degree [odds ratio (OR) 5.98; 95% confidence interval (CI) 2.18-16.39; P < 0.001] was associated with improved odds of patent creation; conversely, practicing surgeon PIs affected patent creation negatively (OR 0.31; 95% CI 0.11-0.85; P = 0.024).

CONCLUSION

In the last decade, a greater proportion of NIH grants in DoS were awarded to more experienced investigators. Disparities exist among grantees, and female investigators are underrepresented, especially among practicing surgeons.

摘要

目的

本研究旨在评估美国国立卫生研究院（NIH）授予外科研究人员的 NIH 资助的当代趋势，包括潜在的差异。

背景

NIH 仍然是美国外科研究的主要公共资金来源；然而，资助和受资助者的模式知之甚少。

方法

使用 NIH RePORTER 对 2008 年至 2018 年期间授予外科系（DoS）的新 R01、R03、R21 赠款进行了查询。从机构网站和/或专业社交媒体账户中提取了主要研究者（PI）的公开信息。

结果

NIH 在过去 10 年中授予了 1101 项新赠款（总计：389006782 美元；中位数：313030 美元）。在过去的 10 年中，DoS 的资金翻了一番（2008 年至 2018 年期间，22983500 美元至 49446076 美元）。中西部/东南部机构和外科肿瘤学家占了大部分赠款（分别为 31.9%和 24.5%）。只有 24.7%的项目由女性 PI 领导，他们主要是非医师 PhD 科学家（52% vs 37.7%仅为 PhD 的男性 PI；P=0.002）。在此期间，拥有超过 15 年经验的 PI 获得的赠款从 12.4%显著增加到 31.7%。这些赠款与 8215 项出版物相关；然而，只有 13.2%发表在高影响力期刊（影响因子≥10）上。4.4%的赠款产生了专利，这些专利与更高的奖励金额相关（345801 美元与 311350 美元；P=0.030）。在多变量分析中，综合 MD/PhD 学位[比值比（OR）5.98；95%置信区间（CI）2.18-16.39；P<0.001]与专利创造的可能性增加相关；相反，执业外科医师 PI 对专利创造产生负面影响（OR 0.31；95%CI 0.11-0.85；P=0.024）。