Yan Lin, Luo Yukun, Zhang Ying, Zhu Yaqiong, Xiao Jing, Lan Yu, Tian Xiaoqi, Song Qing, Xie Fang
Medical School of Chinese PLA, No.28 Fuxing Road, Haidian District, Beijing, China.
Department of Ultrasound, First Medical Center, Chinese PLA General Hospital, No.28 Fuxing Road, Haidian District, Beijing, China.
J Cancer. 2020 Jul 9;11(18):5257-5263. doi: 10.7150/jca.42673. eCollection 2020.
To evaluate the clinical application of core-needle biopsy (CNB) for low-risk papillary thyroid microcarcinoma (PTMC) after radiofrequency ablation (RFA) A total of 202 patients with 211 low-risk PTMCs were included in this study. RFA procedure was used the hydrodissection technique and moving-shot technique. Patients were followed at 1, 3, 6, 12 months and every 6 months thereafter. The volume of ablation area and the volume reduction ratio (VRR) were calculated. At 3 or 6 months after RFA, CNB was performed to the central zone, the peripheral zone and surrounding thyroid parenchyma for post-ablation evaluation. The mean volume of tumors was 102.34±93.84 mm (range 4.19-424.10 mm), which decreased significantly to 1.37±7.74 mm (range 0-73.30 mm) at a mean follow-up time of 24.42±9.15 months (range 3-42 months) with a mean VRR of 99.14±4.18% (range 71.88-100%). A total of 3 ablation areas had positive CNB in the peripheral zone and underwent additional RFA. No recurrent or suspicious metastatic lymph nodes were detected CNB is a feasible and effective evaluation for low-risk PTMC after RFA, which can detect residual cancer cells early.
为评估射频消融（RFA）后粗针穿刺活检（CNB）在低风险甲状腺微小乳头状癌（PTMC）中的临床应用，本研究共纳入202例患者的211个低风险PTMC。RFA采用水分离技术和移动射击技术。患者在术后1、3、6、12个月进行随访，此后每6个月随访一次。计算消融区体积和体积缩小率（VRR）。在RFA后3或6个月，对中央区、外周区和周围甲状腺实质进行CNB以进行消融后评估。肿瘤平均体积为102.34±93.84mm（范围4.19 - 424.10mm），在平均随访时间24.42±9.15个月（范围3 - 42个月）时显著减小至1.37±7.74mm（范围0 - 73.30mm），平均VRR为99.14±4.18%（范围71.88 - 100%）。共有3个消融区在外周区CNB呈阳性并接受了额外的RFA。未检测到复发或可疑转移淋巴结。CNB是RFA后对低风险PTMC进行评估的一种可行且有效的方法，可早期检测残留癌细胞。
