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大鼠坐骨神经损伤模型中钙循环相关因子与肌肉力量的关系

Relationship between calcium circulation-related factors and muscle strength in rat sciatic nerve injury model.

作者信息

Sun Xiaoming, Wang Wei, Dong Yangyi, Wang Yue, Zhang Meixiang, Wang Zhao, Yu Xiaowei, Huang Jiao, Cai Hongxing

机构信息

Department of Forensic Medicine, Xuzhou Medical University, Xuzhou, Jiangsu, P. R. China.

出版信息

Iran J Basic Med Sci. 2020 May;23(5):654-662. doi: 10.22038/IJBMS.2020.40915.9695.

DOI:10.22038/IJBMS.2020.40915.9695
PMID:32742604
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7375001/
Abstract

OBJECTIVES

The purpose of this study is to investigate the indication function of the calcium circulation-related factors on the damage to muscle strength and contraction function after nerve injury. The target factors include ryanodine receptor (RyR), inositol-1,4,5-triphosphate receptor (IP3R), phospholamban (PLN), cryptocalcitonin (CASQ), ATPase and troponin C (TNNC).

MATERIALS AND METHODS

Sprague-Dawley (SD) rats were randomly divided into sham-operated group (SO), sciatic nerve injury group (SNI) and sciatic nerve disconnection group (SNT). Sciatic nerve function index and stretching test were used to examine the changes to muscle strength; bilateral gastrocnemius muscles were extracted after execution for gastrocnemius wet weight ratio test. HE staining slides and average cross-sectional area of muscle fibers were acquired to analyze the muscle atrophy. The transcription level of the factors was also measured.

RESULTS

Sciatic nerve damage in SNI group was significantly higher than that in SO group in the 6 weeks, but there was no significant difference between SNT and SO groups fallowing sciatic nerve damage. Sciatic nerve function in SNT group was worse than that in SNI group. The average cross-sectional area of gastrocnemius muscle fibers in SNI and SNT groups was significantly reduced compared to that in SO group. The transcriptional levels of RyR, PLN, CASQ, ATPase and TNNC in SNI and SNT groups were significantly different from those in SO group.

CONCLUSION

Calcium circulation-related factors could be used as potential indicators for assessment of damages to muscle strength.

摘要

目的

本研究旨在探讨钙循环相关因子对神经损伤后肌肉力量和收缩功能损伤的指示作用。目标因子包括兰尼碱受体（RyR）、肌醇-1,4,5-三磷酸受体（IP3R）、受磷蛋白（PLN）、隐钙素（CASQ）、ATP酶和肌钙蛋白C（TNNC）。

材料与方法

将Sprague-Dawley（SD）大鼠随机分为假手术组（SO）、坐骨神经损伤组（SNI）和坐骨神经离断组（SNT）。采用坐骨神经功能指数和拉伸试验检测肌肉力量变化；处死大鼠后双侧取腓肠肌进行腓肠肌湿重比试验。制作HE染色切片并获取肌纤维平均横截面积以分析肌肉萎缩情况。同时检测各因子的转录水平。

结果

SNI组坐骨神经损伤在6周时显著高于SO组，但SNT组坐骨神经损伤后与SO组相比无显著差异。SNT组坐骨神经功能比SNI组差。SNI组和SNT组腓肠肌纤维平均横截面积与SO组相比显著减小。SNI组和SNT组中RyR、PLN、CASQ、ATP酶和TNNC的转录水平与SO组显著不同。

结论

钙循环相关因子可作为评估肌肉力量损伤的潜在指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f93/7375001/874656f86d8b/IJBMS-23-654-g011.jpg
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