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根治性膀胱切除术后回肠代膀胱原发性弥漫性大B细胞淋巴瘤

Primary diffuse large B-cell lymphoma of the ileal conduit created after radical cystectomy.

作者信息

Nagai Takashi, Okamura Takehiko, Katayama Komei, Chaya Ryosuke, Tanaka Yutaro, Kobayashi Daichi, Kobayashi Takahiro, Akita Hidetoshi, Yasui Takahiro

机构信息

Department of Urology Anjo Kosei Hospital Anjo Japan.

Department of Nephro-Urology Graduate School of Medical Sciences Nagoya City University Nagoya Japan.

出版信息

IJU Case Rep. 2018 Oct 3;1(1):22-24. doi: 10.1002/iju5.12022. eCollection 2018 Nov.

DOI:10.1002/iju5.12022
PMID:32743358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7292145/
Abstract

INTRODUCTION

Creation of an ileal conduit is associated with complications. A few cases have been reported on tumor development in an ileal conduit; diffuse large B-cell lymphoma originating from an ileal conduit is extremely rare.

CASE PRESENTATION

A 62-year-old Japanese man who had undergone radical cystectomy and ileal conduit diversion 6 years previously presented with a whitish bulge that had developed on the surface of the ileal conduit during follow-up visit. Mass biopsy was performed and the histological diagnosis was diffuse large B-cell lymphoma. Positron emission tomography showed no metastatic lesions. We attempted chemotherapy because the tumor cells tested positive for CD20; after six courses of a regimen involving rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone; diffuse large B-cell lymphoma of the ileal conduit resolved gradually. The patient is alive and remains free from the diagnosed diffuse large B-cell lymphoma.

CONCLUSION

We reported an extremely rare case of diffuse large B-cell lymphoma originating from the ileal conduit created after radical cystectomy.

摘要

引言

回肠膀胱术常伴有并发症。有少数关于回肠膀胱内肿瘤发生的病例报道；起源于回肠膀胱的弥漫性大B细胞淋巴瘤极为罕见。

病例报告

一名62岁的日本男性，6年前接受了根治性膀胱切除术及回肠膀胱术，在随访期间，其回肠膀胱表面出现了一个白色隆起。进行了肿块活检，组织学诊断为弥漫性大B细胞淋巴瘤。正电子发射断层扫描显示无转移病灶。由于肿瘤细胞CD20检测呈阳性，我们尝试进行化疗；在接受了六个疗程包含利妥昔单抗、环磷酰胺、阿霉素、长春新碱和泼尼松的方案治疗后，回肠膀胱的弥漫性大B细胞淋巴瘤逐渐消退。患者目前存活，且未再出现已确诊的弥漫性大B细胞淋巴瘤。

结论

我们报告了一例极为罕见的起源于根治性膀胱切除术后所造回肠膀胱的弥漫性大B细胞淋巴瘤病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c85/7292145/d69630665fdc/IJU5-1-22-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c85/7292145/6481d55f256b/IJU5-1-22-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c85/7292145/e2651e3be78a/IJU5-1-22-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c85/7292145/d69630665fdc/IJU5-1-22-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c85/7292145/6481d55f256b/IJU5-1-22-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c85/7292145/e2651e3be78a/IJU5-1-22-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c85/7292145/d69630665fdc/IJU5-1-22-g003.jpg

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本文引用的文献

1
A treatment refractory CD30-positive diffuse large B cell lymphoma in the ileal neobladder.一例回肠新膀胱中治疗难治性CD30阳性弥漫性大B细胞淋巴瘤
Ann Hematol. 2017 Apr;96(4):683-684. doi: 10.1007/s00277-016-2908-3. Epub 2016 Dec 28.
2
Gastrointestinal lymphomas: Morphology, immunophenotype and molecular features.胃肠道淋巴瘤：形态学、免疫表型和分子特征。
J Gastrointest Oncol. 2012 Sep;3(3):209-25. doi: 10.3978/j.issn.2078-6891.2012.024.
3
Diffuse large B-cell lymphoma arising primarily at the stoma after bladder reconstruction using ileal conduit.
主要发生于回肠代膀胱术后造口处的弥漫性大B细胞淋巴瘤。
Intern Med. 2012;51(6):643-6. doi: 10.2169/internalmedicine.51.6851. Epub 2012 Mar 15.
4
Primary gastrointestinal lymphoma.原发性胃肠道淋巴瘤。
World J Gastroenterol. 2011 Feb 14;17(6):697-707. doi: 10.3748/wjg.v17.i6.697.
5
Case report: lymphoma arising in an ileal pouch anal anastomosis after immunomodulatory therapy for inflammatory bowel disease.
Clin Gastroenterol Hepatol. 2006 Aug;4(8):1030-4. doi: 10.1016/j.cgh.2006.05.024. Epub 2006 Jul 18.
6
Autoimmune and chronic inflammatory disorders and risk of non-Hodgkin lymphoma by subtype.自身免疫性和慢性炎症性疾病与非霍奇金淋巴瘤各亚型的风险
J Natl Cancer Inst. 2006 Jan 4;98(1):51-60. doi: 10.1093/jnci/djj004.
7
Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine.接受硫唑嘌呤和6-巯基嘌呤治疗的炎症性肠病患者患淋巴瘤的风险增加。
Gut. 2005 Aug;54(8):1121-5. doi: 10.1136/gut.2004.049460.
8
Lymphoma in an ileostomy.回肠造口术相关淋巴瘤
Postgrad Med J. 2002 Jun;78(920):368-9. doi: 10.1136/pmj.78.920.368.
9
Report on a workshop convened to discuss the pathological and staging classifications of gastrointestinal tract lymphoma.关于召开的讨论胃肠道淋巴瘤病理及分期分类的研讨会报告
Ann Oncol. 1994 May;5(5):397-400. doi: 10.1093/oxfordjournals.annonc.a058869.
10
Primary stomal lymphoma. An unusual complication of ileostomy in a patient with transfusion-related acquired immune deficiency syndrome.原发性造口淋巴瘤。一名输血相关获得性免疫缺陷综合征患者回肠造口术的罕见并发症。
Cancer. 1990 Feb 15;65(4):1028-32. doi: 10.1002/1097-0142(19900215)65:4<1028::aid-cncr2820650431>3.0.co;2-y.