Mahomoodally Mohamad Fawzi, Sadeer Nabeelah, Edoo Mehtaab, Venugopala Katharigatta N
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Department of Health Sciences, Faculty of Science, University of Mauritius, Reduit 80835, Mauritius.
Mini Rev Med Chem. 2021;21(18):2731-2746. doi: 10.2174/1389557520666200730160911.
Phytocompounds isolated from plants are well appraised for their broad pharmacological propensities in several pathologies. One key benefit of phytoconstituents is their relatively low toxicity and adverse effects. Nonetheless, poor solubility, permeation, and poor specificity at the target site tend to hinder its therapeutic efficacy. Hence, novel technologies for drug delivery systems are being developed via the use of various nanoformulation strategies to overcome these challenges and give uniform medication focusing at the dynamic site in desired concentration and improved therapeutic efficacy. Such approaches comprise of novel drug delivery systems (NDDS). The utilisation of herbal formulations for NDDS is more beneficial and advantageous as opposed to others. The utilisation of ethosome, liposome, emulsion, phytosomes, microsphere, and strong lipid nanoparticles of herbal formulation has improved the remedial impacts of plant extricates. With the utilisation of all these, directed delivery of the formulation is accomplished, because of which the formulation exhibits impact on the site, and its' bioavailability is, likewise, expanded. With these novel medication conveyance frameworks, the actives and concentrates, which are utilised as part of natural formulations, exhibit a sustained release, enhancement in stability, improved therapeutic efficacy, and protection from toxicity. The primary motivation behind creating alternative drug delivery technologies is to expand the effectiveness of drug conveyance and safety in the process and give more comfort to the patient. In this review, the importance of various phytocompounds in the delivery of drugs is highlighted as well as their importance in reducing the risk or diseases.
从植物中分离出的植物化合物因其在多种病症中具有广泛的药理特性而备受赞誉。植物成分的一个关键优势是其相对较低的毒性和副作用。然而，溶解度差、渗透性差以及在靶位点的特异性差往往会阻碍其治疗效果。因此，正在通过使用各种纳米制剂策略来开发新型药物递送系统技术，以克服这些挑战，并以所需浓度在动态部位实现均匀给药并提高治疗效果。这些方法包括新型药物递送系统（NDDS）。与其他方法相比，将草药制剂用于NDDS更有益且更具优势。草药制剂的乙醇脂质体、脂质体、乳剂、植物脂质体、微球和固体脂质纳米粒的应用提高了植物提取物的治疗效果。通过使用所有这些，实现了制剂的定向递送，因此制剂在该部位发挥作用，其生物利用度也得以提高。借助这些新型药物递送系统，用于天然制剂的活性成分和提取物表现出缓释、稳定性增强、治疗效果改善以及免受毒性影响。开发替代药物递送技术的主要动机是提高药物递送过程中的有效性和安全性，并为患者提供更多便利。在本综述中，强调了各种植物化合物在药物递送中的重要性以及它们在降低疾病风险方面的重要性。
