Department of Biological Informatics and Experimental Therapeutics, Graduate School of Medicine, Akita University, 1-1-1 Hondo, Akita, 010-8543, Japan.
Section on Molecular Signal Transduction, Eunice Kennedy Shriver National Institutes of Child Health and Human Development, National Institutes of Health, 35A Convent Drive, Bethesda, MD 20892-3752, USA.
J Biochem. 2020 Oct 1;168(4):329-336. doi: 10.1093/jb/mvaa089.
Inositol phospholipids are low-abundance regulatory lipids that orchestrate diverse cellular functions in eukaryotic organisms. Recent studies have uncovered involvement of the lipids in multiple steps in autophagy. The late endosome-lysosome compartment plays critical roles in cellular nutrient sensing and in the control of both the initiation of autophagy and the late stage of eventual degradation of cytosolic materials destined for elimination. It is particularly notable that inositol lipids are involved in almost all steps of the autophagic process. In this review, we summarize how inositol lipids regulate and contribute to autophagy through the endomembrane compartments, primarily focusing on PI4P and PI(4,5)P2.
肌醇磷脂是含量较低的调节性脂质，在真核生物中协调多种细胞功能。最近的研究揭示了脂质在自噬的多个步骤中的参与。晚期内体-溶酶体隔室在细胞营养感应以及自噬的起始和最终用于消除的细胞质物质的晚期降解的控制中起着关键作用。特别值得注意的是，肌醇脂质参与自噬过程的几乎所有步骤。在这篇综述中，我们总结了肌醇脂质如何通过内膜隔室调节和促进自噬，主要集中在 PI4P 和 PI(4,5)P2 上。
