IEEE Trans Biomed Eng. 2021 Mar;68(3):1066-1073. doi: 10.1109/TBME.2020.3004983. Epub 2021 Feb 18.
The current challenge in the field of thermo-ablative treatments of tumors is to achieve a balance between complete destruction of malignant cells and safeguarding of the surrounding healthy tissue. Blood perfusion plays a key role for thermal ablation success, especially in the case of highly vascularized organs like liver. This work aims at monitoring the temperature within perfused swine liver undergoing laser ablation (LA). Temperature was measured through seven arrays of Fiber Bragg Grating sensors (FBGs) around the laser applicator. To mimic reality, blood perfusion within the ex-vivo liver was simulated using artificial vessels. The influence of blood perfusion on LA was carried out by comparing the temperature profiles in two different spatial configurations of vessels and fibers. The proposed setup permitted to accurately measure the heat propagation in real-time with a temperature resolution of 0.1 °C and to observe a relevant tissue cooling near to the vessel up to 65%.
目前，肿瘤热消融治疗领域的挑战是在彻底破坏恶性细胞和保护周围健康组织之间取得平衡。血液灌注对于热消融的成功起着关键作用，特别是在肝脏等血管丰富的器官中。本工作旨在监测接受激光消融（LA）的灌注猪肝内的温度。通过围绕激光施加点的七个光纤布拉格光栅传感器（FBG）阵列来测量温度。为了模拟现实，使用人工血管模拟离体肝内的血液灌注。通过比较两种不同血管和光纤空间配置下的温度曲线，研究了血液灌注对 LA 的影响。所提出的设置允许以 0.1°C 的温度分辨率实时准确地测量热传播，并观察到靠近血管的组织冷却可达 65%。
