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S-MRUT:用于脑植入物选择性供电的扇形多环超声换能器。

S-MRUT: Sectored-Multiring Ultrasonic Transducer for Selective Powering of Brain Implants.

作者信息

Hosseini Seyedsina, Laursen Kjeld, Rashidi Amin, Mondal Tanmay, Corbett Brian, Moradi Farshad

出版信息

IEEE Trans Ultrason Ferroelectr Freq Control. 2021 Jan;68(1):191-200. doi: 10.1109/TUFFC.2020.3001084. Epub 2020 Dec 23.

Abstract

One of the main challenges of the current ultrasonic transducers for powering brain implants is the complexity of focusing ultrasonic waves in various axial and lateral directions. The available transducers usually use electrically controlled phased array for beamforming the ultrasonic waves, which increases the complexity of the system even further. In this article, we propose a straightforward solution for selective powering of brain implants to remove the complexity of conventional phased arrays. Our approach features a Sectored-Multiring Ultrasonic Transducer (S-MRUT) on a single piezoelectric sheet, specifically designed for powering implantable devices for optogenetics in freely moving animals. The proposed unidirectional S-MRUT is capable of focusing the ultrasonic waves on brain implants located at different depths and regions of the brain. The S-MRUT is designed based on Fresnel Zone Plate (FZP) theory, simulated in COMSOL, and fabricated with the microfabrication process. The acoustic profile of the seven different configurations of the S-MRUT was measured using a hydrophone with the total number of 7436 grid points. The measurements show the ability of the proposed S-MRUT to sweep the focus point of the acoustic waves in the axial direction in depths of 1 - 3 mm, which is suitable for powering implants in the striatum of the mouse. Furthermore, the proposed S-MRUT demonstrates a steering area with an average radius of 0.862 mm and 0.678 mm in experiments and simulations, respectively. The S-MRUT is designed with the size of 3.8×3.8×0.5 mm and the weight of 0.054gr , showing that it is compact and light enough to be worn by a mouse. Finally, the S-MRUT was tested in our measurement setup, where it successfully transfers sufficient power to a 2.8-mm optogentic stimulator to turn on a micro-LED on the stimulator.

摘要

当前用于为脑植入物供电的超声换能器面临的主要挑战之一是在各个轴向和横向方向上聚焦超声波的复杂性。现有的换能器通常使用电控相控阵来对超声波进行波束形成,这进一步增加了系统的复杂性。在本文中,我们提出了一种为脑植入物选择性供电的直接解决方案,以消除传统相控阵的复杂性。我们的方法的特点是在单个压电片上采用扇形多环超声换能器(S-MRUT),专门设计用于为自由活动动物中的光遗传学植入式设备供电。所提出的单向S-MRUT能够将超声波聚焦在位于大脑不同深度和区域的脑植入物上。S-MRUT基于菲涅耳波带片(FZP)理论进行设计,在COMSOL中进行模拟,并通过微加工工艺制造。使用具有7436个网格点的水听器测量了S-MRUT的七种不同配置的声学轮廓。测量结果表明,所提出的S-MRUT能够在1-3毫米深度的轴向方向上扫描声波的焦点,这适用于为小鼠纹状体中的植入物供电。此外,所提出的S-MRUT在实验和模拟中分别展示了平均半径为0.862毫米和0.678毫米的转向区域。S-MRUT的尺寸设计为3.8×3.8×0.5毫米,重量为0.054克,表明它足够紧凑和轻便,可以由小鼠佩戴。最后,S-MRUT在我们的测量装置中进行了测试,在该装置中它成功地将足够的功率传输到一个2.8毫米的光遗传学刺激器,以打开刺激器上的微型发光二极管。

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