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新型冠状病毒肺炎与广泛的肺动脉、心内及外周动脉血栓形成有关。

COVID-19 associated with extensive pulmonary arterial, intracardiac and peripheral arterial thrombosis.

作者信息

Ferguson Katie, Quail Nathaniel, Kewin Peter, Blyth Kevin G

机构信息

Department of Respiratory Medicine, Queen Elizabeth University Hospital, Glasgow, UK.

College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.

出版信息

BMJ Case Rep. 2020 Aug 3;13(8):e237460. doi: 10.1136/bcr-2020-237460.

Abstract

We describe a patient with COVID-19 who developed simultaneous pulmonary, intracardiac and peripheral arterial thrombosis. A 58-year-old man, without major comorbidity, was admitted with a 14-day history of breathlessness. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection was confirmed by laboratory testing. Initial imaging revealed COVID-19 pneumonia but no pulmonary thromboembolism (PTE) on CT pulmonary angiography (CTPA). The patient subsequently developed respiratory failure and left foot ischaemia associated with a rising D-dimer. Repeat CTPA and lower limb CT angiography revealed simultaneous bilateral PTE, biventricular cardiac thrombi and bilateral lower limb arterial occlusions. This case highlights a broad range of vascular sequalae associated with COVID-19 and the fact that these can occur despite a combination of prophylactic and treatment dose anticoagulation.

摘要

我们描述了一名新冠肺炎患者,其同时发生了肺部、心内和外周动脉血栓形成。一名58岁男性,无重大合并症,因14天的呼吸困难病史入院。实验室检测确诊为严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染。初始影像学检查显示为新冠肺炎肺炎,但CT肺动脉造影(CTPA)未发现肺血栓栓塞症(PTE)。该患者随后出现呼吸衰竭和左脚缺血,同时D-二聚体升高。重复CTPA和下肢CT血管造影显示同时存在双侧PTE、双心室心脏血栓和双侧下肢动脉闭塞。本病例突出了与新冠肺炎相关的广泛血管后遗症,以及尽管联合使用了预防性和治疗剂量的抗凝药物,这些后遗症仍可能发生的事实。

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