Department of Ophthalmology, Heinrich-Heine-University Düsseldorf, Moorenstraße 5, 40225, Düsseldorf, Germany.
Asklepios Nord Eye Hospital, Hamburg, Germany.
Int Ophthalmol. 2020 Nov;40(11):3097-3104. doi: 10.1007/s10792-020-01532-z. Epub 2020 Aug 3.
Dry eye symptoms after conventional cataract surgery are a very common problem. Until now, only few data are available on objective tear film parameters in regard to femtosecond laser-assisted cataract surgery (LCS). Aim of this study was therefore to analyze and compare tear film parameter changes between LCS and conventional cataract surgery.
A consecutive group of 34 patients, scheduled for cataract surgery, were randomly selected for either LCS or conventional cataract surgery (17 patients/group). Tear film assessments including tear film osmolarity, Schirmer test, MMP-9 analysis via quantitative ELISA, corneal sensitivity, corneal fluorescein staining, and conjunctival fluorescein staining were sequentially evaluated pre- as well as 1 and 3 months postoperatively.
Both groups showed no significant difference in baseline characteristics. All surgeries were performed without any complications. After 1 and 3 months, there was no statistically significant difference in regard to tear film osmolarity (1 month: p = 0.81, 3 months: p = 1.0), Schirmer test (1 month: p = 0.35, 3 month: p = 0.08), and MMP-9 concentration (1 month: p = 0.36, 3 month: p = 0.28) between the two groups.
Neither LCS nor conventional cataract surgery affected objective tear film parameters significantly during our 3-month postoperative observation period. Hence, both surgical techniques can be equally used to treat patients without prior dry eye symptoms.
传统白内障手术后的干眼症状是一个非常普遍的问题。到目前为止，关于飞秒激光辅助白内障手术（LCS）的客观泪膜参数仅有少量数据。因此，本研究旨在分析和比较 LCS 与传统白内障手术之间的泪膜参数变化。
连续选择 34 例计划行白内障手术的患者，随机分为 LCS 组或传统白内障手术组（每组 17 例）。术前及术后 1 个月和 3 个月，分别进行泪膜评估，包括泪膜渗透压、泪液分泌试验、通过定量 ELISA 分析 MMP-9、角膜敏感性、角膜荧光素染色和结膜荧光素染色。
两组患者的基线特征均无显著差异。所有手术均无并发症。术后 1 个月和 3 个月，两组的泪膜渗透压（1 个月：p=0.81，3 个月：p=1.0）、泪液分泌试验（1 个月：p=0.35，3 个月：p=0.08）和 MMP-9 浓度（1 个月：p=0.36，3 个月：p=0.28）均无统计学差异。
在我们的 3 个月术后观察期内，LCS 和传统白内障手术均未显著影响客观泪膜参数。因此，两种手术技术均可用于治疗无先前干眼症状的患者。
