Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA.
Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, GA, USA.
Transpl Infect Dis. 2021 Feb;23(1):e13435. doi: 10.1111/tid.13435. Epub 2020 Aug 16.
Adenovirus infection is commonly associated with self-limited respiratory and gastrointestinal illnesses. However, infection in immunocompromised individuals, such as transplant recipients, can cause severe life-threatening illness including pneumonitis, hemorrhagic cystitis, nephritis, hepatitis, and enterocolitis. In orthotopic liver transplant recipients, adenovirus viremia can cause hepatitis leading to marked transaminitis, allograft loss, and death. Although hepatic abscesses mediated by adenovirus have been described in other immunosuppressed patient populations, it has very rarely been described in liver transplant recipients. Here, we report two adult cases of hepatic abscesses following liver transplantation secondary to adenovirus infection and describe the successful treatment of these patients. Adenovirus should be considered as an uncommon etiology of hepatic abscess and unexplained fevers in adults following liver transplantation.
腺病毒感染通常与自限性呼吸道和胃肠道疾病有关。然而，在免疫功能低下的个体（如移植受者）中，感染可导致严重的危及生命的疾病，包括肺炎、出血性膀胱炎、肾炎、肝炎和肠炎。在原位肝移植受者中，腺病毒血症可导致肝炎，导致显著的转氨酶升高、移植物丢失和死亡。虽然在其他免疫抑制患者群体中已经描述了腺病毒引起的肝脓肿，但在肝移植受者中很少有描述。在这里，我们报告了两例继发于腺病毒感染的肝移植后肝脓肿的成年病例，并描述了这些患者的成功治疗。腺病毒应被视为肝移植后成人不明原因肝脓肿和发热的一种罕见病因。
