伴侣犬的脂代谢随年龄和体重的变化。
Alterations of Lipid Metabolism With Age and Weight in Companion Dogs.
机构信息
Department of Biology, University of Alabama at Birmingham.
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria.
出版信息
J Gerontol A Biol Sci Med Sci. 2021 Feb 25;76(3):400-405. doi: 10.1093/gerona/glaa186.
The companion dog has recently been promoted as powerful translational model of aging. However, while dogs share environments with their human owners and develop many of the same age-related morbidities, little is known about the underlying mechanisms that drive their health and longevity. In addition, dogs have a well described phenotypic pattern in which small dogs live significantly longer than large dogs, such that weight can be used as a crude proxy for longevity. To investigate this pattern, we completed a small lipidomics study on 41 dogs in the Birmingham, Alabama, United States, area to determine individual circulating lipids that were associated with age and body weight. We discovered that sphingomyelins were significantly higher in large, short-lived dogs, independent of age, and triglycerides were higher in older dogs of all sizes. Our results point towards physiological differences that may explain a portion of the variation in longevity seen in companion dogs.
伴侣犬最近被提升为强大的衰老转化模型。然而，尽管狗与它们的人类主人共享环境，并患上许多相同的与年龄相关的疾病，但对于驱动它们健康和长寿的潜在机制知之甚少。此外，狗具有一种特征明显的表型模式，即小型犬的寿命明显长于大型犬，因此体重可以作为衡量寿命的粗略指标。为了研究这种模式，我们对美国阿拉巴马州伯明翰地区的 41 只狗进行了一项小型脂质组学研究，以确定与年龄和体重相关的个体循环脂质。我们发现，鞘磷脂在大型、短命的狗中明显升高，与年龄无关，而甘油三酯在所有大小的老年狗中都升高。我们的研究结果表明，生理差异可能解释了伴侣犬寿命差异的一部分原因。
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