FLUID Team, Lyon Neurosciences Research Center, INSERM U1028 CNRS UMR 5292, University Claude Bernard Lyon 1, 69008 Lyon, France; Friedensgasse 3, 8010 Graz, Austria.
Department of Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, Medicinaregatan 11, Box 432, 40530 Göteborg, Sweden.
Biochim Biophys Acta Biomembr. 2020 Nov 1;1862(11):183430. doi: 10.1016/j.bbamem.2020.183430. Epub 2020 Aug 1.
The choroid plexus (CP) is located in the ventricular system of the brain (one in each ventricle), and the CP epithelial cells form an important barrier between the blood and the cerebrospinal fluid (CSF). Their main function comprises CSF secretion, maintenance of brain homeostasis, signalling, and forming a neuroprotective barrier against harmful external and internal compounds. The CPs mature early and demonstrate expressional changes of barrier-specific genes and proteins related to location and developmental stage of the CP. Important proteins for the barrier function include tight junction proteins, numerous transporters and enzymes. Natural senescence leads to structural changes in the CP cells and reduced or loss of function, while further loss of CP function and changes in immune status may be relevant in neurodegenerative diseases such as Alzheimer's disease and Multiple Sclerosis. Neuroprotective genes expressed at CPs may be unexplored targets for new therapies for neurodegenerative diseases.
脉络丛位于脑的脑室系统中（每个脑室一个），脉络丛上皮细胞在血液和脑脊液（CSF）之间形成重要的屏障。它们的主要功能包括 CSF 分泌、维持脑内环境稳定、信号传递以及形成针对有害内外化合物的神经保护屏障。脉络丛成熟较早，并表现出与 CP 位置和发育阶段相关的屏障特异性基因和蛋白质的表达变化。对屏障功能很重要的蛋白质包括紧密连接蛋白、许多转运蛋白和酶。自然衰老导致 CP 细胞的结构变化和功能降低或丧失，而 CP 功能的进一步丧失和免疫状态的变化可能与阿尔茨海默病和多发性硬化症等神经退行性疾病有关。在脉络丛中表达的神经保护基因可能是神经退行性疾病新疗法的未开发靶点。
