Department of Mining-Metallurgy Engineering and Materials Science, School of Engineering EIB 1, University of the Basque Country (UPV/EHU) and Polymat, 48013 Bilbao, Spain.
Center for Research in Medical Devices (CÚRAM), National University of Ireland (NUIG), Newcastle Road, H91 W2TY Galway, Ireland.
Int J Mol Sci. 2020 Jul 31;21(15):5480. doi: 10.3390/ijms21155480.
This work reports the versatility of polydopamine (PD) when applied as a particle coating in a composite of polylactide (PLA). Polydopamine was observed to increase the particle-matrix interface strength and facilitate the adsorption of drugs to the material surface. Here, barium sulfate radiopaque particles were functionalized with polydopamine and integrated into a polylactide matrix, leading to the formulation of a biodegradable and X-ray opaque material with enhanced mechanical properties. Polydopamine functionalized barium sulfate particles also facilitated the adsorption and release of the antibiotic levofloxacin. Analysis of the antibacterial capacity of these composites and the metabolic activity and proliferation of human dermal fibroblasts in vitro demonstrated that these materials are non-cytotoxic and can be 3D printed to formulate complex biocompatible materials for bone fixation devices.
这项工作报道了聚多巴胺（PD）作为聚乳酸（PLA）复合材料中的颗粒涂层的多功能性。聚多巴胺被观察到可以提高颗粒-基体界面强度，并促进药物吸附到材料表面。在这里，硫酸钡不透射线颗粒用聚多巴胺进行功能化，并整合到聚乳酸基体中，从而形成一种具有增强机械性能的可生物降解和 X 射线不透光材料。聚多巴胺功能化硫酸钡颗粒还促进了抗生素左氧氟沙星的吸附和释放。对这些复合材料的抗菌能力以及体外人皮肤成纤维细胞的代谢活性和增殖的分析表明，这些材料无细胞毒性，可以进行 3D 打印，以制定用于骨固定装置的复杂生物相容性材料。
