Zhuang Hanqiong, Su Huilin, Bi Xuexin, Bai Yuting, Chen Lu, Ge Dongtao, Shi Wei, Sun Yanan
Key Laboratory of Biomedical Engineering of Fujian Province University/Research Center of Biomedical Engineering of Xiamen, Fujian Key Laboratory of Materials Genome, Department of Biomaterials, College of Materials, Xiamen University, No. 422, Siming South Road, Xiamen 361005, P. R. China.
ACS Biomater Sci Eng. 2017 Aug 14;3(8):1799-1808. doi: 10.1021/acsbiomaterials.7b00260. Epub 2017 Jul 11.
Polydopamine capsule has aroused wide attention since its emergence, because of its biocompatibility and the great potential as drug delivery carrier. However, preparing the nanometer PDA capsule (PDAC) is still remained a challenge, especially with the size below 300 nm. Moreover, there is little research about its photoacoustic imaging (PAI) and photothermal therapy (PTT) effect. In this paper, we reported an improved DMDES emulsion template method to obtain 200 nm PDAC, and act as highly efficient theranostic agent for photoacoustic imaging (PAI) and chemo-photothermal synergistic therapy. Due to its hollow structure and the higher photothermal conversion efficiency (η), the PDAC showed excellent PAI ability as its PA intensity was far outweigh the PBS and over two folders than the same size polydopamine particles (PDAP) at the same concentration in vitro. The animal experiment also verified this conclusion. Then the anticancer drug-doxorubicin (DOX) was loaded on PDAC via electrostatic interaction and π-π stacking. Moreover, the drug release was pH responsive and NIR laser responsive to minimize the side effect, and this system was proved to efficiently ablate the tumor in vitro and in vivo experiments. This research highlights the great potential of PDA capsule as a new theranostic agent.
聚多巴胺胶囊自出现以来就引起了广泛关注，因其具有生物相容性以及作为药物递送载体的巨大潜力。然而，制备纳米聚多巴胺胶囊（PDAC）仍然是一个挑战，尤其是尺寸低于300nm的情况。此外，关于其光声成像（PAI）和光热疗法（PTT）效果的研究很少。在本文中，我们报道了一种改进的DMDES乳液模板法来获得200nm的PDAC，并将其用作光声成像（PAI）和化学-光热协同治疗的高效诊疗剂。由于其空心结构和较高的光热转换效率（η），PDAC在体外相同浓度下表现出优异的PAI能力，其PA强度远远超过PBS，比相同尺寸的聚多巴胺颗粒（PDAP）高出两倍多。动物实验也验证了这一结论。然后通过静电相互作用和π-π堆积将抗癌药物阿霉素（DOX）负载到PDAC上。此外，药物释放具有pH响应性和近红外激光响应性，以尽量减少副作用，并且该系统在体外和体内实验中均被证明能有效消融肿瘤。这项研究突出了PDA胶囊作为一种新型诊疗剂的巨大潜力。
