Institute of Biology, Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.
Department of Pathogen Biology and Immunology, Institute of Genetics and Microbiology, University of Wroclaw, Przybyszewskiego 63-77, 51-148 Wrocław, Poland.
Molecules. 2020 Jul 31;25(15):3492. doi: 10.3390/molecules25153492.
Metal complexes are currently potential therapeutic compounds. The acquisition of resistance by cancer cells or the effective elimination of cancer-affected cells necessitates a constant search for chemical compounds with specific biological activities. One alternative option is the transition metal complexes having potential as antitumor agents. Here, we present the current knowledge about the application of transition metal complexes bearing nickel(II), cobalt(II), copper(II), ruthenium(III), and ruthenium(IV). The cytotoxic properties of the above complexes causing apoptosis, autophagy, DNA damage, and cell cycle inhibition are described in this review.
金属配合物是目前有潜力的治疗化合物。为了使癌细胞产生耐药性或有效消除受癌细胞影响的细胞，需要不断寻找具有特定生物活性的化合物。一种替代选择是具有抗肿瘤作用的过渡金属配合物。在这里，我们介绍了目前关于含镍(II)、钴(II)、铜(II)、钌(III)和钌(IV)的过渡金属配合物的应用知识。本综述描述了上述配合物通过诱导细胞凋亡、自噬、DNA 损伤和细胞周期抑制产生细胞毒性的特性。
