Department of General and Medical Biochemistry, Faculty of Biology, University of Gdansk, Wita Stwosza 59, 80-308 Gdansk, Poland.
Department of Microbiology, Faculty of Biology, University of Gdansk, Wita Stwosza 59, 80-308 Gdansk, Poland.
Int J Mol Sci. 2020 Jul 31;21(15):5498. doi: 10.3390/ijms21155498.
is considered one of the most persistent pathogens responsible for nosocomial infections. Due to the emergence of multidrug resistant strains, as well as high morbidity and mortality caused by this pathogen, was placed on the World Health Organization (WHO) drug-resistant bacteria and antimicrobial resistance research priority list. This review summarizes current studies on mechanisms that protect against multiple stresses caused by the host immune response, outside host environment, and antibiotic treatment. We particularly focus on the ability of to survive long-term desiccation on abiotic surfaces and the population heterogeneity in biofilms. Insight into these protective mechanisms may provide clues for the development of new strategies to fight multidrug resistant strains of .
被认为是导致医院感染的最持久的病原体之一。由于出现了多药耐药菌株，以及该病原体引起的高发病率和死亡率，已被世界卫生组织（WHO）列入耐药细菌和抗菌药物耐药性研究优先清单。本综述总结了目前关于保护 免受宿主免疫反应、宿主外环境和抗生素治疗引起的多种压力的机制的研究。我们特别关注 在非生物表面长期干燥和生物膜中种群异质性条件下生存的能力。深入了解这些保护机制可能为开发新策略以对抗多药耐药菌株提供线索。
