老药新用：他汀类药物治疗 COVID-19？
Teaching Old Drugs New Tricks: Statins for COVID-19?
机构信息
Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Center for Cytokine Storm Treatment & Laboratory, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Division of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Institute for Translational Medicine and Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
出版信息
Cell Metab. 2020 Aug 4;32(2):145-147. doi: 10.1016/j.cmet.2020.07.006.
The COVID-19 pandemic has driven unprecedented efforts to identify existing treatments that can be quickly and effectively repurposed to reduce morbidity and mortality. In this issue of Cell Metabolism, Zhang et al. (2020) report an association between statin use and improved outcomes in a large observational study of hospitalized COVID-19 patients. Given the widespread availability, low cost, and safety of statins, this promising result should be further investigated in randomized controlled trials.
COVID-19 大流行促使人们前所未有地努力寻找现有治疗方法，以便能够快速有效地重新用于降低发病率和死亡率。在本期《细胞代谢》杂志上，Zhang 等人（2020）报告了一项大型观察性研究中，他汀类药物的使用与住院 COVID-19 患者的改善结局之间的关联。鉴于他汀类药物的广泛可用性、低成本和安全性，这一有希望的结果应该在随机对照试验中进一步研究。
Zotero 插件