Pharmaceutical Technology Department, National Research Centre, Cairo 12622, Egypt.
Cellulose and Paper Department, National Research Centre, Cairo 12622, Egypt.
Int J Biol Macromol. 2020 Nov 15;163:1579-1590. doi: 10.1016/j.ijbiomac.2020.07.242. Epub 2020 Aug 2.
Cellulose was and still is the most abundant biopolymer generated from all plant fibers including agricultural wastes. Using this waste as a starting material in the production of new products is a field of great interest. The demand for renewable and available resources in combination with advanced technologies is a necessity to develop new generations of advanced nanomaterials. This review aims to present integrated details on the extraction techniques and structure of nanofibrillated cellulose as well as cellulose nanocrystals derived from agricultural wastes besides the different treatment methods used to be suitable for several pharmaceutical applications. Different pharmaceutical applications are described, including controlled, sustained or rapid drug delivery, stabilizing agent, and its use as safe and sustained environment for cell culture allowing its use in tissue engineering field.
纤维素曾是、现在依然是最丰富的生物聚合物,它来源于所有植物纤维,包括农业废弃物。以这种废物为原料生产新产品是一个极有吸引力的领域。对可再生资源和现有资源的需求,再加上先进技术,是开发新一代先进纳米材料的必要条件。本综述旨在介绍从农业废弃物中提取纳米原纤纤维素和纤维素纳米晶体的技术和结构的综合细节,以及不同的处理方法,使其适用于几种药物应用。描述了不同的药物应用,包括控制、持续或快速药物输送、稳定剂,以及将其用作细胞培养的安全和持续环境,允许其用于组织工程领域。