Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences (Beijing), Beijing 100083, China; Beijing Engineering Research Center for BioNanotechnology and CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, Beijing 100190, China.
Beijing Engineering Research Center for BioNanotechnology and CAS Key Lab for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology, Beijing 100190, China.
Carbohydr Polym. 2019 Nov 15;224:115144. doi: 10.1016/j.carbpol.2019.115144. Epub 2019 Jul 29.
Scaffolds based on nanocellulose (NC) have crucial applications in tissue engineering (TE) owing to the biocompatibility, water absorption, water retention, optical transparency, and chemo-mechanical properties. In this review, we summarize the scaffolds based on nanocellulose, including nanocrystalline cellulose and nanofibrillated cellulose. We compare four representative methods to prepare NC-based scaffolds, containing electrospinning, freeze-drying, 3D printing, and solvent casting. We outline the characteristics of scaffolds obtained by different methods. Our focus is on the applications of NC-based scaffolds to repair, improve or replace damaged tissues and organs, including skin, blood vessel, nerve, skeletal muscle, heart, liver, and ophthalmology. NC-based scaffolds are attractive materials for regeneration of different tissues and organs due to the remarkable features. Finally, we propose the challenges and potentials of NC-based TE scaffolds.
基于纳米纤维素（NC）的支架在组织工程（TE）中具有重要的应用，因为其具有生物相容性、吸水性、保水性、光学透明性和化学机械性能。在这篇综述中，我们总结了基于纳米纤维素的支架，包括纳米晶纤维素和纳米原纤维纤维素。我们比较了四种制备 NC 基支架的代表性方法，包括静电纺丝、冷冻干燥、3D 打印和溶剂浇铸。我们概述了不同方法得到的支架的特性。我们的重点是 NC 基支架在修复、改善或替代受损组织和器官方面的应用，包括皮肤、血管、神经、骨骼肌、心脏、肝脏和眼科。由于其显著的特点，NC 基支架是用于不同组织和器官再生的有吸引力的材料。最后，我们提出了 NC 基 TE 支架的挑战和潜力。
