多形核白细胞颗粒蛋白对奇异变形杆菌的杀伤作用：抗菌蛋白具有物种特异性的证据。
Killing of Proteus mirabilis by polymorphonuclear leukocyte granule proteins: evidence for species specificity by antimicrobial proteins.
作者信息
Shafer W M, Engle S A, Martin L E, Spitznagel J K
机构信息
Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322.
出版信息
Infect Immun. 1988 Jan;56(1):51-3. doi: 10.1128/iai.56.1.51-53.1988.
Abstract
Low-molecular-weight (Mr, ca. 3,800) polypeptides containing human defensins HNP-1 and HNP-2 (T. Ganz, M. S. Selsted, D. Szlarek, S. L. Harwig, K. Daher, D. F. Bainton, and R. I. Lehrer, J. Clin. Invest. 76:1427-1434, 1985) prepared in our laboratory from acid extracts of human polymorphonuclear granulocyte granules and purified human defensins were found to exert potent bactericidal action against Proteus mirabilis. The antimicrobial action of the extracts of human polymorphonuclear leukocytes granules against P. mirabilis appears to be due to the presence of the defensins. Because P. mirabilis resists the antimicrobial action of other granule proteins, we interpret the present results to mean that the various antimicrobial proteins display species specificity in their microbicidal action.
摘要
在我们实验室中，从人多形核粒细胞颗粒的酸性提取物中制备的含有人类防御素HNP - 1和HNP - 2（T.甘茨、M.S.塞尔斯特德、D.斯扎雷克、S.L.哈维格、K.达赫尔、D.F.班顿和R.I.莱勒，《临床研究杂志》76:1427 - 1434，1985年）的低分子量（分子量约3800）多肽以及纯化的人类防御素，被发现对奇异变形杆菌具有强大的杀菌作用。人多形核白细胞颗粒提取物对奇异变形杆菌的抗菌作用似乎归因于防御素的存在。由于奇异变形杆菌能抵抗其他颗粒蛋白的抗菌作用，我们将目前的结果解释为各种抗菌蛋白在其杀菌作用中表现出种属特异性。
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