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1
Killing of Proteus mirabilis by polymorphonuclear leukocyte granule proteins: evidence for species specificity by antimicrobial proteins.多形核白细胞颗粒蛋白对奇异变形杆菌的杀伤作用：抗菌蛋白具有物种特异性的证据。
Infect Immun. 1988 Jan;56(1):51-3. doi: 10.1128/iai.56.1.51-53.1988.
2
Effect of small cationic leukocyte peptides (defensins) on the permeability barrier of the outer membrane.小阳离子白细胞肽（防御素）对外膜通透性屏障的影响。
Infect Immun. 1988 Sep;56(9):2324-9. doi: 10.1128/iai.56.9.2324-2329.1988.
3
Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils.鉴定防御素-1、防御素-2和CAP37/天青杀素为白细胞介素-8刺激的中性粒细胞释放的T细胞趋化蛋白。
J Biol Chem. 1996 Feb 9;271(6):2935-40. doi: 10.1074/jbc.271.6.2935.
4
Purification and characterization of human neutrophil peptide 4, a novel member of the defensin family.防御素家族新成员——人中性粒细胞肽4的纯化与特性分析
J Biol Chem. 1989 Jul 5;264(19):11200-3.
5
Defensins. Natural peptide antibiotics of human neutrophils.防御素。人类中性粒细胞的天然肽类抗生素。
J Clin Invest. 1985 Oct;76(4):1427-35. doi: 10.1172/JCI112120.
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Monocyte-chemotactic activity of defensins from human neutrophils.人中性粒细胞防御素的单核细胞趋化活性。
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Effect of anaerobic bacteria on killing of Proteus mirabilis by human polymorphonuclear leukocytes.厌氧菌对人多形核白细胞杀灭奇异变形杆菌的影响。
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8
[Investigation of microbicidal activity of neutrophil defensins against leptospires].[中性粒细胞防御素对钩端螺旋体的杀菌活性研究]
Hua Xi Yi Ke Da Xue Xue Bao. 1992 Jun;23(2):126-9.
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[Activity of defensins from human neutrophils against Mycobacterium avium complex].[人中性粒细胞防御素对鸟分枝杆菌复合群的活性]
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Primary structures of three human neutrophil defensins.三种人类中性粒细胞防御素的一级结构。
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Bioactive Antimicrobial Peptides as Therapeutics for Corneal Wounds and Infections.生物活性抗菌肽作为角膜创伤和感染的治疗药物。
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Synthetic bactericidal peptide based on CAP37: a 37-kDa human neutrophil granule-associated cationic antimicrobial protein chemotactic for monocytes.基于CAP37的合成杀菌肽：一种37 kDa的人中性粒细胞颗粒相关阳离子抗菌蛋白，对单核细胞具有趋化作用。
Proc Natl Acad Sci U S A. 1993 May 15;90(10):4733-7. doi: 10.1073/pnas.90.10.4733.
3
Effect of lipopolysaccharide (LPS) chain length on interactions of bactericidal/permeability-increasing protein and its bioactive 23-kilodalton NH2-terminal fragment with isolated LPS and intact Proteus mirabilis and Escherichia coli.脂多糖（LPS）链长度对杀菌/通透性增加蛋白及其具有生物活性的23千道尔顿氨基末端片段与分离的LPS以及完整的奇异变形杆菌和大肠杆菌相互作用的影响。
Infect Immun. 1994 Jan;62(1):259-65. doi: 10.1128/iai.62.1.259-265.1994.
4
In vitro sensitivity of oral, gram-negative, facultative bacteria to the bactericidal activity of human neutrophil defensins.口腔革兰氏阴性兼性细菌对人中性粒细胞防御素杀菌活性的体外敏感性
Infect Immun. 1990 Dec;58(12):3934-40. doi: 10.1128/iai.58.12.3934-3940.1990.
5
Antibiotic proteins of human neutrophils.人类中性粒细胞的抗生素蛋白。
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6
Differential killing of Actinobacillus actinomycetemcomitans and Capnocytophaga spp. by human neutrophil granule components.人中性粒细胞颗粒成分对伴放线放线杆菌和二氧化碳嗜纤维菌属的差异性杀伤作用。
Infect Immun. 1991 Oct;59(10):3760-7. doi: 10.1128/iai.59.10.3760-3767.1991.
7
Agents that increase the permeability of the outer membrane.增加外膜通透性的制剂。
Microbiol Rev. 1992 Sep;56(3):395-411. doi: 10.1128/mr.56.3.395-411.1992.

本文引用的文献

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Cationic antimicrobial proteins isolated from human neutrophil granulocytes in the presence of diisopropyl fluorophosphate.在二异丙基氟磷酸存在的情况下从人中性粒细胞中分离出的阳离子抗菌蛋白。
Infect Immun. 1984 Jul;45(1):29-35. doi: 10.1128/iai.45.1.29-35.1984.
2
Chemical structure of the lipid A component of the lipopolysaccharide from a Proteus mirabilis Re-mutant.奇异变形杆菌Re-突变体脂多糖中脂质A成分的化学结构。
Eur J Biochem. 1983 Dec 1;137(1-2):15-22. doi: 10.1111/j.1432-1033.1983.tb07789.x.
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Characterization of the lipopolysaccharide from the polymyxin-resistant pmrA mutants of Salmonella typhimurium.鼠伤寒沙门氏菌多粘菌素抗性pmrA突变体脂多糖的特性分析
FEBS Lett. 1981 Jun 29;129(1):145-9. doi: 10.1016/0014-5793(81)80777-6.
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Lipid A and resistance of Salmonella typhimurium to antimicrobial granule proteins of human neutrophil granulocytes.脂质A与鼠伤寒沙门氏菌对人中性粒细胞抗菌颗粒蛋白的抗性
Infect Immun. 1984 Mar;43(3):834-8. doi: 10.1128/iai.43.3.834-838.1984.
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Arginine-rich proteins of polymorphonuclear leukocyte lysosomes. Antimicrobial specificity and biochemical heterogeneity.多形核白细胞溶酶体富含精氨酸的蛋白质。抗菌特异性和生化异质性。
J Exp Med. 1968 May 1;127(5):927-41. doi: 10.1084/jem.127.5.927.
6
Defensins mediate the microbicidal activity of human neutrophil granule extract against Acinetobacter calcoaceticus.防御素介导人中性粒细胞颗粒提取物对醋酸钙不动杆菌的杀菌活性。
Infect Immun. 1987 Jun;55(6):1365-8. doi: 10.1128/iai.55.6.1365-1368.1987.
7
Late intraphagosomal hydrogen ion concentration favors the in vitro antimicrobial capacity of a 37-kilodalton cationic granule protein of human neutrophil granulocytes.吞噬体内晚期氢离子浓度有利于人中性粒细胞中一种37千道尔顿阳离子颗粒蛋白的体外抗菌能力。
Infect Immun. 1986 Sep;53(3):651-5. doi: 10.1128/iai.53.3.651-655.1986.
8
A spontaneous mutant of Neisseria gonorrhoeae with decreased resistance to neutrophil granule proteins.一株对中性粒细胞颗粒蛋白抗性降低的淋病奈瑟菌自发突变体。
J Infect Dis. 1986 May;153(5):910-7. doi: 10.1093/infdis/153.5.910.
9
Defensins. Natural peptide antibiotics of human neutrophils.防御素。人类中性粒细胞的天然肽类抗生素。
J Clin Invest. 1985 Oct;76(4):1427-35. doi: 10.1172/JCI112120.
10
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.一种利用蛋白质 - 染料结合原理对微克级蛋白质进行定量的快速灵敏方法。
Anal Biochem. 1976 May 7;72:248-54. doi: 10.1016/0003-2697(76)90527-3.

多形核白细胞颗粒蛋白对奇异变形杆菌的杀伤作用：抗菌蛋白具有物种特异性的证据。

Killing of Proteus mirabilis by polymorphonuclear leukocyte granule proteins: evidence for species specificity by antimicrobial proteins.

作者信息

Shafer W M, Engle S A, Martin L E, Spitznagel J K

机构信息

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322.

出版信息

Infect Immun. 1988 Jan;56(1):51-3. doi: 10.1128/iai.56.1.51-53.1988.

DOI:10.1128/iai.56.1.51-53.1988
PMID:3275586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC259232/
Abstract

Low-molecular-weight (Mr, ca. 3,800) polypeptides containing human defensins HNP-1 and HNP-2 (T. Ganz, M. S. Selsted, D. Szlarek, S. L. Harwig, K. Daher, D. F. Bainton, and R. I. Lehrer, J. Clin. Invest. 76:1427-1434, 1985) prepared in our laboratory from acid extracts of human polymorphonuclear granulocyte granules and purified human defensins were found to exert potent bactericidal action against Proteus mirabilis. The antimicrobial action of the extracts of human polymorphonuclear leukocytes granules against P. mirabilis appears to be due to the presence of the defensins. Because P. mirabilis resists the antimicrobial action of other granule proteins, we interpret the present results to mean that the various antimicrobial proteins display species specificity in their microbicidal action.

摘要

在我们实验室中，从人多形核粒细胞颗粒的酸性提取物中制备的含有人类防御素HNP - 1和HNP - 2（T.甘茨、M.S.塞尔斯特德、D.斯扎雷克、S.L.哈维格、K.达赫尔、D.F.班顿和R.I.莱勒，《临床研究杂志》76:1427 - 1434，1985年）的低分子量（分子量约3800）多肽以及纯化的人类防御素，被发现对奇异变形杆菌具有强大的杀菌作用。人多形核白细胞颗粒提取物对奇异变形杆菌的抗菌作用似乎归因于防御素的存在。由于奇异变形杆菌能抵抗其他颗粒蛋白的抗菌作用，我们将目前的结果解释为各种抗菌蛋白在其杀菌作用中表现出种属特异性。