基因多态性与骨质疏松症风险的关联：荟萃分析。

Associations between polymorphisms in gene and the risk of osteoporosis: a meta-analysis.

机构信息

Department of Diabetes, Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China.

Department of Traumatology and Orthopedics, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.

出版信息

Arch Physiol Biochem. 2022 Dec;128(6):1637-1644. doi: 10.1080/13813455.2020.1787457. Epub 2020 Aug 6.

DOI:10.1080/13813455.2020.1787457

PMID:32757960

Abstract

The authors conducted this meta-analysis to robustly estimate relationships between polymorphisms in gene and the risk of osteoporosis by integrating the results of previous works. Medline, Embase, Wanfang, VIP and CNKI were searched thoroughly for eligible studies, and 73 genetic association studies were finally included in this meta-analysis. We noticed that ApaI rs7975232, BsmI rs1544410 and TaqI rs731236 polymorphisms were significantly associated with the risk of osteoporosis in Caucasians. Moreover, BsmI rs1544410 and FokI rs10735810 polymorphisms were significantly associated with the risk of osteoporosis in Asians. In conclusion, this meta-analysis demonstrates that ApaI rs7975232, BsmI rs1544410 and TaqI rs731236 polymorphisms may influence the risk of osteoporosis in Caucasians, while BsmI rs1544410 and TaqI rs731236 polymorphisms may influence the risk of osteoporosis in Asians.

摘要

作者进行了这项荟萃分析，通过整合先前研究的结果，稳健地估计了基因多态性与骨质疏松症风险之间的关系。全面检索了 Medline、Embase、万方、VIP 和 CNKI 以获取符合条件的研究，最终有 73 项遗传关联研究纳入了这项荟萃分析。我们注意到 ApaI rs7975232、BsmI rs1544410 和 TaqI rs731236 多态性与高加索人群骨质疏松症的风险显著相关。此外，BsmI rs1544410 和 FokI rs10735810 多态性与亚洲人群骨质疏松症的风险显著相关。总之，这项荟萃分析表明，ApaI rs7975232、BsmI rs1544410 和 TaqI rs731236 多态性可能影响高加索人群骨质疏松症的风险，而 BsmI rs1544410 和 TaqI rs731236 多态性可能影响亚洲人群骨质疏松症的风险。