University of Nebraska Medical Center, Omaha, NE, USA.
Bellevue Hospital Center, New York, NY, USA.
Int J Infect Dis. 2020 Oct;99:233-242. doi: 10.1016/j.ijid.2020.07.042. Epub 2020 Aug 3.
This article summarizes the countermeasures for Marburg virus disease, focusing on pathogenesis, clinical features and diagnostics. There is an emphasis on therapies and vaccines that have demonstrated, through their evaluation in nonhuman primates (NHPs) and/or in humans, potential for use in an emergency situation.
A standardized literature review was conducted on vaccines and treatments for Marburg virus disease, with a focus on human and nonhuman primate data published in the last five years. More detail on the methods that were used is summarized in a companion methods paper.
The study identified six treatments and four vaccine platforms that have demonstrated, through their efficacy in NHPs, potential benefit for treating or preventing infection in humans.
Succinct summaries of Marburg countermeasures are provided to give the busy clinician a head start in reviewing the literature if faced with a patient with Marburg virus disease. Links to other authoritative sources of information are also provided.
本文总结了马尔堡病毒病的对策，重点介绍了发病机制、临床特征和诊断。强调了通过在非人类灵长类动物（NHPs）和/或人类中进行评估，显示出在紧急情况下可能使用的疗法和疫苗。
对马尔堡病毒病的疫苗和治疗方法进行了标准化文献回顾，重点关注过去五年中在人和非人类灵长类动物中发表的数据。在一份配套的方法文件中总结了更详细的方法信息。
该研究确定了六种治疗方法和四种疫苗平台，它们在 NHP 中的疗效表明对人类感染的治疗或预防具有潜在益处。
如果临床医生遇到马尔堡病毒病患者，本文提供了简明的马尔堡对策摘要，以便他们快速查阅文献。还提供了其他权威信息来源的链接。
