Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Yoshida, Sakyo-ku, Kyoto, 606-8501, Japan.
Chem Commun (Camb). 2020 Aug 25;56(68):9750-9766. doi: 10.1039/d0cc03740k.
The discovery of NO, CO, and H2S as gasotransmitters and their beneficial role in multiple physiological functions opened an era of research devoted to exogenously delivering them as therapeutic agents. However, the gaseous nature of these molecules demands new forms of administration that enable one to control the location, dosage and timing of their delivery. Porous materials are among the most suitable scaffolds to store, deliver and release gasotransmitters due to their high surface area, tunable composition and reactivity. This review highlights the strategies employed to load and release gasotransmitters from different kinds of porous materials, including zeolites, mesoporous silica, metal-organic frameworks and protein assemblies.
一氧化氮（NO）、一氧化碳（CO）和硫化氢（H2S）作为气体递质的发现及其在多种生理功能中的有益作用开创了一个专门研究将它们作为治疗剂外源性递送来的时代。然而，这些分子的气态性质要求采用新的给药形式，以便能够控制它们的递达位置、剂量和时间。由于具有高表面积、可调节的组成和反应性，多孔材料是储存、递送和释放气体递质的最合适的支架之一。本综述重点介绍了从不同类型的多孔材料（包括沸石、介孔硅、金属有机骨架和蛋白质组装体）中加载和释放气体递质所采用的策略。
