FastBMD：一种用于转录组数据快速基准剂量-反应分析的在线工具。
FastBMD: an online tool for rapid benchmark dose-response analysis of transcriptomics data.
机构信息
Department of Natural Resource Sciences, McGill University, Montreal, QC H9X 3V9, Canada.
Institute of Parasitology, McGill University, Montreal, QC H9X 3V9, Canada.
出版信息
Bioinformatics. 2021 May 17;37(7):1035-1036. doi: 10.1093/bioinformatics/btaa700.
MOTIVATION
Transcriptomics dose-response analysis is a promising new approach method for toxicity testing. While international regulatory agencies have spent substantial effort establishing a standardized statistical approach, existing software that follows this approach is computationally inefficient and must be locally installed.
RESULTS
FastBMD is a web-based tool that implements standardized methods for transcriptomics benchmark dose-response analysis in R. It is >60 times faster than the current leading software, supports transcriptomics data from 13 species, and offers a comprehensive analytical pipeline that goes from processing and normalization of raw gene expression values to interactive exploration of pathway-level benchmark dose results.
AVAILABILITY AND IMPLEMENTATION
FastBMD is freely available at www.fastbmd.ca.
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online.
动机
转录组剂量反应分析是一种很有前途的毒性测试新方法。虽然国际监管机构已经投入了大量精力来建立标准化的统计方法，但现有的遵循这种方法的软件在计算效率上效率低下，并且必须在本地安装。
结果
FastBMD 是一个基于网络的工具，它在 R 中实现了转录组基准剂量反应分析的标准化方法。它比当前领先的软件快 60 多倍，支持来自 13 个物种的转录组数据，并提供了一个全面的分析管道，从处理和标准化原始基因表达值到交互式探索途径水平基准剂量结果。
可用性和实现
FastBMD 可在 www.fastbmd.ca 上免费获得。
补充信息
补充数据可在“Bioinformatics”在线获得。
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