Mangi R J, Greco T, Ryan J, Thornton G, Andriole V T
Hospital of Saint Raphael, New Haven, Connecticut 06511.
Am J Med. 1988 Jan;84(1):68-74. doi: 10.1016/0002-9343(88)90010-1.
Cefoperazone monotherapy was compared with combination antibiotic therapy in a randomized prospective evaluation of patients with hospital-acquired pneumonia. Cefoperazone was as effective as either clindamycin/gentamicin or cefazolin/gentamicin (cure rate: 45 of 52 cefoperazone-treated patients [87 percent], versus 44 of 61 combination-therapy patients [72 percent], p = 0.069). With the exception of hypoprothrombinemia in those patients who did not receive prophylactic vitamin K, there was no difference in the incidence of side effects. In addition, no difference was noted in the incidence of superinfections or secondary pneumonias. When antibiotic costs, administration costs, and laboratory costs were considered, cefoperazone monotherapy was the least expensive antibiotic regimen. Cefoperazone is a suitable alternative to combination antibiotic therapy for the treatment of hospital-acquired pneumonia.
在一项针对医院获得性肺炎患者的随机前瞻性评估中，对头孢哌酮单药治疗与联合抗生素治疗进行了比较。头孢哌酮的疗效与克林霉素/庆大霉素或头孢唑林/庆大霉素相当（治愈率：52例接受头孢哌酮治疗的患者中有45例[87%]，而61例联合治疗患者中有44例[72%]，p = 0.069）。除了未接受预防性维生素K的患者出现低凝血酶原血症外，副作用发生率没有差异。此外，在二重感染或继发性肺炎的发生率方面未观察到差异。当考虑抗生素成本、给药成本和实验室成本时，头孢哌酮单药治疗是最便宜的抗生素治疗方案。头孢哌酮是治疗医院获得性肺炎的联合抗生素治疗的合适替代方案。
