College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China.
Anhui Province Key Laboratory of Chinese Medicinal Formula, Hefei, Anhui, 230012, China.
ChemMedChem. 2020 Oct 19;15(20):1940-1946. doi: 10.1002/cmdc.202000263. Epub 2020 Sep 10.
Controversial biodegradability and nonspecific pre-drug leakage are major limitations for inorganic nanoparticles in cancer treatment. To solve these problems, we developed organic-inorganic hybridized hollow mesoporous silica nanoparticles with polydopamine modifications on the surface to simultaneously achieve enhanced biodegradability and controllable drug release. The morphology and chemical structure of the nanoparticles were characterized by TEM, N adsorption-desorption isotherms, TEM-mapping and XPS. Moreover, the release behavior of nanoparticles under various pH conditions and the degradation behavior in the presence of GSH were evaluated. With effective controlled release, HMONs-PTX@PDA were shown to significantly inhibit cancer cell proliferation and achieve antitumor effects in vivo through dual-response release in the tumor microenvironment. Overall, this nanoplatform has significant potential to achieve tumor microenvironment-responsive degradation and release to enhance tumor accumulation, which is very promising for cancer treatment.
无机纳米粒子在癌症治疗中存在生物降解性和非特异性预药物泄漏等问题，限制了其应用。为了解决这些问题，我们开发了具有聚多巴胺修饰表面的有机-无机杂化中空介孔硅纳米粒子，以同时实现增强的生物降解性和可控药物释放。通过 TEM、N2 吸附-解吸等温线、TEM 映射和 XPS 对纳米粒子的形态和化学结构进行了表征。此外，还评估了纳米粒子在不同 pH 条件下的释放行为以及在 GSH 存在下的降解行为。通过在肿瘤微环境中进行双重响应释放，HMONs-PTX@PDA 实现了有效的控制释放，显著抑制了癌细胞增殖，并在体内发挥了抗肿瘤作用。总的来说，这种纳米平台具有实现肿瘤微环境响应性降解和释放以增强肿瘤积累的巨大潜力，非常有希望用于癌症治疗。
