Department of Vascular Medicine, Peking University Shougang Hospital, Beijing, P. R. of China.
Department of Interventional Vascular Surgery, Peking University Third Hospital, Beijing, P. R. of China.
J Int Med Res. 2020 Aug;48(8):300060520940157. doi: 10.1177/0300060520940157.
This retrospective single-center study aimed to analyze immediate and follow-up results of using drug-coated balloons (DCBs) for treating peripheral arterial disease.
In this study, we identified a total of 75 patients who underwent DCB therapy at our institution. The ankle-brachial index (ABI) was measured before and after intervention. Intermittent claudication and whether there was healing of ulcers were determined by telephone.
The cohort consisted of 56 men and 19 women aged 38 to 87 years (68 ± 12 years). Twenty-three patients had Rutherford grade III, 15 had Rutherford grade IV, and 37 had Rutherford grade V. Seventeen patients had stents and 18 had the Rotarex system used. The postoperative ABI was significantly greater than the preoperative ABI (0.911 ± 0.173 vs 0.686 ± 0.249). Good results for treatment were obtained. Intermittent claudication and rest pain did not occur in subjects with Rutherford grades III and IV during follow-up. The amputation rate was 4.1% among all patients using DCB therapy during follow-up.
DCB therapy is safe and effective for treating peripheral arterial disease in real-world patients. Future prospective studies on this issue are recommended.
本回顾性单中心研究旨在分析使用药物涂层球囊（DCB）治疗外周动脉疾病的即刻和随访结果。
本研究共纳入 75 例在我院接受 DCB 治疗的患者。干预前后测量踝肱指数（ABI）。通过电话确定间歇性跛行和溃疡是否愈合。
队列包括 56 名男性和 19 名女性，年龄 38 至 87 岁（68±12 岁）。23 例患者为 Rutherford 分级 III 级，15 例为 Rutherford 分级 IV 级，37 例为 Rutherford 分级 V 级。17 例患者植入支架，18 例患者使用 Rotarex 系统。术后 ABI 明显大于术前 ABI（0.911±0.173 比 0.686±0.249）。治疗效果良好。在随访期间，Rutherford 分级 III 和 IV 的患者均未出现间歇性跛行和静息痛。所有接受 DCB 治疗的患者中有 4.1%需要截肢。
DCB 治疗在外周动脉疾病的真实世界患者中是安全且有效的。建议对此问题进行前瞻性研究。
