AB 家族变异体 rs1800977、rs4149313 和 rs1128503 与中国汉族人群 2 型糖尿病易感性的关联。
Association between ABC family variants rs1800977, rs4149313, and rs1128503 and susceptibility to type 2 diabetes in a Chinese Han population.
机构信息
Department of Gastrointestinal Surgery, East Section of Renmin Hospital of Wuhan University, Wuhan, China.
Department of Bariatric Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
出版信息
J Int Med Res. 2020 Aug;48(8):300060520941347. doi: 10.1177/0300060520941347.
OBJECTIVE
To investigate the association between three single nucleotide polymorphisms (SNPs) of the ATP-binding cassette (ABC) gene family and susceptibility to type 2 diabetes mellitus in a Chinese Han population.
METHODS
A total of 1086 type 2 diabetes patients and 1122 healthy controls were included in this retrospective study. Three genetic variants, rs1800977 and rs4149313 in , and rs1128503 in were included in the study. Susceptibility to type 2 diabetes was evaluated under three genetic models.
RESULTS
A significant association between rs1800977 and type 2 diabetes was identified in three different genetic models (TT vs CC, odds ratio [OR] = 0.611 [95% confidence interval (CI), 0.469-0.798]; T vs C, OR = 0.841 [95% CI, 0.745-0.950]; and the recessive model, OR = 0.606 [95% CI, 0.474-0.774]). Additionally, a significant association between rs4149313 and type 2 diabetes was identified in three different genetic models (AA vs GG, OR = 0.467 [95% CI, 0.326-0.670]; A vs G, OR = 0.819 [95% CI, 0.717-0.935]; and the recessive model, OR = 0.478 [95% CI, 0.336-0.680]).
CONCLUSION
We found that SNPs rs1800977 and rs4149313 in are significantly associated with susceptibility to type 2 diabetes in a Chinese population, although this should be confirmed in a larger study.
目的
探讨中国汉族人群三核苷酸结合盒（ABC）基因家族中的三个单核苷酸多态性（SNP）与 2 型糖尿病易感性的关系。
方法
本回顾性研究共纳入 1086 例 2 型糖尿病患者和 1122 例健康对照者。研究纳入了 、和中的三个遗传变异体 rs1800977 和 rs4149313 以及 rs1128503。采用三种遗传模型评估 2 型糖尿病的易感性。
结果
在三种不同的遗传模型（TT 与 CC，比值比[OR] = 0.611 [95%置信区间（CI），0.469-0.798]；T 与 C，OR = 0.841 [95% CI，0.745-0.950]；以及隐性模型，OR = 0.606 [95% CI，0.474-0.774]）中，rs1800977 与 2 型糖尿病显著相关。此外，在三种不同的遗传模型（AA 与 GG，OR = 0.467 [95% CI，0.326-0.670]；A 与 G，OR = 0.819 [95% CI，0.717-0.935]；以及隐性模型，OR = 0.478 [95% CI，0.336-0.680]）中，rs4149313 与 2 型糖尿病显著相关。
结论
我们发现，在中国人群中， 中的 SNPs rs1800977 和 rs4149313 与 2 型糖尿病易感性显著相关，但这需要在更大的研究中得到证实。
Zotero 插件