Department of Medical Care for Cadres, Zhejiang Hospital, 12 Lingyin Road, Hangzhou, Zhejiang, China.
Department of Medical Care for Cadres, Zhejiang Hospital, 12 Lingyin Road, Hangzhou, Zhejiang, China
Biosci Rep. 2018 Mar 9;38(2). doi: 10.1042/BSR20171632. Print 2018 Apr 27.
ATP-binding cassette transporter A1 (ABCA1) is associated with serum high-density lipoprotein (HDL) levels. Several studies have demonstrated that individuals with a high HDL cholesterol level have a reduced risk of incident type 2 diabetes mellitus (T2DM). Therefore, we conducted a case-control study including 508 T2DM patients and 614 controls to explore the association between the ABCA1 rs1800977 polymorphism and T2DM risk in a Chinese Han population. Genotyping was performed using matrix-assisted laser desorption/lionization time-of-flight mass spectrometry. Our results indicate that the TT genotype of the rs1800977 polymorphism was associated with a decreased risk of T2DM compared to the CC genotype. The T allele of the rs1800977 polymorphism was also related with a decreased risk of T2DM. There was no significant association between clinical parameters (HDL, low-density lipoprotein, cholesterol, body mass index, and age) and rs1800977 polymorphism genotypes. In conclusion, the ABCA1 rs1800977 polymorphism may contribute to the development of T2DM. However, larger studies with more diverse ethnic populations are needed to confirm these results.
三磷酸腺苷结合盒转运体 A1（ABCA1）与血清高密度脂蛋白（HDL）水平相关。多项研究表明，HDL 胆固醇水平高的个体发生 2 型糖尿病（T2DM）的风险降低。因此，我们进行了一项病例对照研究，纳入了 508 例 T2DM 患者和 614 例对照，以探讨中国汉族人群中 ABCA1 rs1800977 多态性与 T2DM 风险之间的关系。采用基质辅助激光解吸/电离飞行时间质谱法进行基因分型。我们的结果表明，与 CC 基因型相比，rs1800977 多态性的 TT 基因型与 T2DM 风险降低相关。rs1800977 多态性的 T 等位基因也与 T2DM 风险降低相关。rs1800977 多态性与临床参数（HDL、低密度脂蛋白、胆固醇、体重指数和年龄）之间没有显著关联。总之，ABCA1 rs1800977 多态性可能导致 T2DM 的发生。然而，需要更大规模的、更多样化的种族人群研究来证实这些结果。
