College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, South Korea.
Front Endocrinol (Lausanne). 2021 Apr 23;12:639524. doi: 10.3389/fendo.2021.639524. eCollection 2021.
The ATP-binding cassette transporter A1 is likely associated with the risk of type 2 diabetes mellitus (T2DM) β cell function modification, but the evidence on the association remains unclear. This study aimed to investigate the relationship between the 69C>T polymorphism and the risk of T2DM through a systematic review and meta-analysis.
The PubMed, Web of Science, and Embase databases were searched for qualified studies published until August 2020. Studies that included the association between the 69C>T polymorphism and the risk of T2DM were reviewed. The odds ratios (ORs) and 95% confidence intervals (CIs) were evaluated.
We analyzed data from a total of 10 studies involving 17,742 patients. We found that the CC or CT genotype was associated with increased risk of T2DM than the TT genotype (OR, 1.41; 95% CI, 1.02-1.93). In the Asian population, the C allele carriers had a higher risk of T2DM than those with the TT genotype; the ORs of the CC and CT genotypes were 1.80 (95% CI, 1.21-2.68) and 1.61 (95% CI, and 1.29-2.01), respectively.
This meta-analysis confirmed that the 69C>T genotype showed a decrease risk of T2DM compared to the CC or CT genotypes.
ATP 结合盒转运蛋白 A1 可能与 2 型糖尿病（T2DM）β细胞功能改变的风险相关，但关于该相关性的证据仍不清楚。本研究旨在通过系统评价和荟萃分析来探讨 69C>T 多态性与 T2DM 风险之间的关系。
检索 PubMed、Web of Science 和 Embase 数据库，纳入截至 2020 年 8 月发表的合格研究。评估 69C>T 多态性与 T2DM 风险之间的关联研究。评估比值比（ORs）和 95%置信区间（CIs）。
我们分析了共 10 项研究的数据，这些研究共纳入了 17742 名患者。我们发现 CC 或 CT 基因型与 T2DM 风险增加有关，而 TT 基因型则不然（OR，1.41；95%CI，1.02-1.93）。在亚洲人群中，C 等位基因携带者发生 T2DM 的风险高于 TT 基因型携带者；CC 和 CT 基因型的 OR 值分别为 1.80（95%CI，1.21-2.68）和 1.61（95%CI，1.29-2.01）。
这项荟萃分析证实，与 CC 或 CT 基因型相比，69C>T 基因型与 T2DM 风险降低有关。
