Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh.
Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka 1000, Bangladesh.
Gene. 2019 Mar 10;688:151-154. doi: 10.1016/j.gene.2018.12.003. Epub 2018 Dec 7.
ATP-binding cassette transporter 1 (ABCA1) gene polymorphism has been reported as one of the genetic risk factors for T2DM in various populations with conflicting results. The aim of this study is to investigate the association of ABCA1 C69T polymorphism and lipid profile with T2DM in Bangladeshi population.
A total of 102 T2DM subjects and 98 healthy controls were recruited and their genotypes for ABCA1 gene polymorphisms were determined based on the PCR-RFLP technique. Serum lipid profiles (total cholesterol, HDL-C, LDL-C and TG) were also estimated by using standard methods.
ABCA 1 (C69T) genotypes frequencies were estimated. The percentages of CC, CT and TT genotypes at 69 position of ABCA1 gene were 31.63%, 58.16% and 10.21% in control as well as 22.54%, 69.60% and 7.86% in diabetes group respectively. Significant association was not found between ABCA1 (C69T) genotypes and T2DM in Bangladeshi population (Odd Ratio: 1.67; 95% Confidence Interval: 0.88 to 3.19 for CT genotype and Odd Ratio: 1.07; Confidence Interval: 0.36 to 3.16 for TT genotype; p > 0.05). Serum lipid profiles were not associated with T2DM.
ABCA1 gene polymorphism might not be a genetic risk factor for T2DM subjects among Bangladeshis. We did not find a relationship between genotypes and lipid concentrations in our two groups. Study with a larger sample size will help us to understand the relationship of ABCA1 C69T genotype and lipid profile with T2DM.
ATP 结合盒转运蛋白 1（ABCA1）基因多态性已被报道为不同人群 2 型糖尿病（T2DM）的遗传危险因素之一，但结果存在冲突。本研究旨在探讨 ABCA1 C69T 多态性与脂质谱与孟加拉国人群 T2DM 的相关性。
共招募 102 例 T2DM 患者和 98 例健康对照者，采用 PCR-RFLP 技术检测 ABCA1 基因多态性。采用标准方法测定血清脂质谱（总胆固醇、HDL-C、LDL-C 和 TG）。
估计 ABCA1（C69T）基因型频率。ABCA1 基因 69 位 CC、CT 和 TT 基因型的百分比在对照组分别为 31.63%、58.16%和 10.21%，在糖尿病组分别为 22.54%、69.60%和 7.86%。在孟加拉国人群中，ABCA1（C69T）基因型与 T2DM 之间无显著相关性（OR：1.67；95%CI：0.88 至 3.19 为 CT 基因型，OR：1.07；95%CI：0.36 至 3.16 为 TT 基因型；p>0.05）。血清脂质谱与 T2DM 无关。
ABCA1 基因多态性可能不是孟加拉国 T2DM 患者的遗传危险因素。我们在两组人群中未发现基因型与脂质浓度之间存在关系。更大样本量的研究将有助于我们了解 ABCA1 C69T 基因型与脂质谱与 T2DM 的关系。
