两对对映贝壳杉烷倍半萜类立体异构体，双去氢莪术酮 D-G，来自姜黄的根茎。
Two pairs of bisabolane sesquiterpenoid stereoisomers, bisacurone D-G, from the rhizome of Curcuma longa L.
机构信息
Yunnan Institute of Materia Medica, Kunming 650111, China; Innovation and R&D Center, Yunnan Bai Yao Group, Kunming 650111, China; Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation, Kunming 650111, China.
Yunnan Institute of Materia Medica, Kunming 650111, China; Innovation and R&D Center, Yunnan Bai Yao Group, Kunming 650111, China; Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation, Kunming 650111, China.
出版信息
Fitoterapia. 2020 Oct;146:104701. doi: 10.1016/j.fitote.2020.104701. Epub 2020 Aug 4.
Phytochemical investigation of an extract of the rhizome of Curcuma longa L., resulted in the identification of four undescribed bisabolane sesquiterpenoids, namely as bisacurone D-G (1-4). With the aid of comprehensive spectroscopic techniques (NMR, IR, UV, MS), the structures of all isolated compounds were elucidated and subsequently screened for both anti-inflammatory and cytotoxic biological activities, Compounds 1 and 2 showed moderate inhibitory activity toward LPS-induced NO production on RAW 264.7 macrophages.
从姜黄根茎的提取物中进行的植物化学研究，鉴定出了四种未被描述的倍半萜类化合物，即双姜黄酮 D-G（1-4）。借助综合光谱技术（NMR、IR、UV、MS），阐明了所有分离化合物的结构，并随后对其进行了抗炎和细胞毒性生物活性筛选。化合物 1 和 2 对 LPS 诱导的 RAW 264.7 巨噬细胞中 NO 产生具有中等抑制活性。
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