Kim Jiwoong, Choi Seongwook, Kim Chulhong, Kim Jeesu, Park Byullee
Departments of Electrical Engineering, Convergence IT Engineering, Medical Science and Engineering, Mechanical Engineering, and Medical Device Innovation Center, Pohang University of Science and Technology (POSTECH), Cheongam-ro 77, Nam-gu, Pohang 37673, Republic of Korea.
Departments of Cogno-Mechatronics Engineering and Optics & Mechatronics Engineering, Pusan National University, Busan 46241, Republic of Korea.
Pharmaceutics. 2024 Sep 24;16(10):1240. doi: 10.3390/pharmaceutics16101240.
Photoacoustic imaging (PAI) is an emerging noninvasive and label-free method for capturing the vasculature, hemodynamics, and physiological responses following drug delivery. PAI combines the advantages of optical and acoustic imaging to provide high-resolution images with multiparametric information. In recent decades, PAI's abilities have been used to determine reactivity after the administration of various drugs. This study investigates photoacoustic imaging as a label-free method of monitoring drug delivery responses by observing changes in the vascular system and oxygen saturation levels across various biological tissues. In addition, we discuss photoacoustic studies that monitor the biodistribution and pharmacokinetics of exogenous contrast agents, offering contrast-enhanced imaging of diseased regions. Finally, we demonstrate the crucial role of photoacoustic imaging in understanding drug delivery mechanisms and treatment processes.
光声成像（PAI）是一种新兴的非侵入性且无需标记的方法，用于在药物递送后捕获血管系统、血流动力学和生理反应。PAI结合了光学成像和声学成像的优点，以提供具有多参数信息的高分辨率图像。在最近几十年中，PAI的能力已被用于确定各种药物给药后的反应性。本研究通过观察不同生物组织中血管系统和氧饱和度水平的变化，研究光声成像作为一种监测药物递送反应的无需标记的方法。此外，我们讨论了监测外源性造影剂的生物分布和药代动力学的光声研究，这些研究提供了病变区域的对比增强成像。最后，我们证明了光声成像在理解药物递送机制和治疗过程中的关键作用。
