School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou 325000, China.
Division of Gastroenterology and Hepatology, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Int J Mol Sci. 2020 Aug 5;21(16):5598. doi: 10.3390/ijms21165598.
As an essential organelle in nucleated eukaryotic cells, mitochondria play a central role in energy metabolism, maintenance of redox balance, and regulation of apoptosis. Mitochondrial dysfunction, either due to the TCA cycle enzyme defects, mitochondrial DNA genetic mutations, defective mitochondrial electron transport chain, oxidative stress, or aberrant oncogene and tumor suppressor signaling, has been observed in a wide spectrum of human cancers. In this review, we summarize mitochondrial dysfunction induced by these alterations that promote human cancers.
作为有核真核细胞的重要细胞器，线粒体在能量代谢、氧化还原平衡的维持和细胞凋亡的调控中起着核心作用。无论是三羧酸循环酶缺陷、线粒体 DNA 遗传突变、线粒体电子传递链缺陷、氧化应激还是异常的癌基因和抑癌基因信号，都观察到了广泛的人类癌症中线粒体功能障碍。在这篇综述中，我们总结了这些改变导致的线粒体功能障碍促进人类癌症的发生机制。
