Raimondo Stefania, Urzì Ornella, Conigliaro Alice, Raimondi Lavinia, Amodio Nicola, Alessandro Riccardo
Department of Biomedicine, Neurosciences and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, Italy.
IRCSS Istituto Ortopedico Rizzoli, SC Scienze e Tecnologie Chirurgiche-SS Piattaforma Scienze Omiche per Ortopedia Personalizzata, 40136 Bologna, Italy.
Noncoding RNA. 2020 Aug 5;6(3):30. doi: 10.3390/ncrna6030030.
Increasing evidence indicates that extracellular vesicles (EVs) released from both tumor cells and the cells of the bone marrow microenvironment contribute to the pathobiology of multiple myeloma (MM). Recent studies on the mechanisms by which EVs exert their biological activity have indicated that the non-coding RNA (ncRNA) cargo is key in mediating their effect on MM development and progression. In this review, we will first discuss the role of EV-associated ncRNAs in different aspects of MM pathobiology, including proliferation, angiogenesis, bone disease development, and drug resistance. Finally, since ncRNAs carried by MM vesicles have also emerged as a promising tool for early diagnosis and therapy response prediction, we will report evidence of their potential use as clinical biomarkers.
越来越多的证据表明，肿瘤细胞和骨髓微环境细胞释放的细胞外囊泡（EVs）参与了多发性骨髓瘤（MM）的病理生物学过程。最近关于EVs发挥其生物活性机制的研究表明，非编码RNA（ncRNA）货物在介导其对MM发展和进展的影响中起关键作用。在本综述中，我们将首先讨论EV相关ncRNAs在MM病理生物学不同方面的作用，包括增殖、血管生成、骨病发展和耐药性。最后，由于MM囊泡携带的ncRNAs也已成为早期诊断和治疗反应预测的有前途的工具，我们将报告它们作为临床生物标志物潜在用途的证据。
