Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo, 173-8605, Japan.
Department of Surgery, Koga Hospital, Yaizu, Japan.
Sci Rep. 2020 Aug 6;10(1):13239. doi: 10.1038/s41598-020-70252-2.
The Controlling Nutritional Status (CONUT) score is a marker of nutrition and is associated with poor survival in various kinds of cancers. However, no reports have yet compared risk factors for colorectal cancer recurrence using a nutritional index. We assessed the predictive value of the CONUT score compared with the modified Glasgow Prognostic Score (mGPS) and Prognostic Nutritional Index (PNI) in colorectal cancer (CRC) patients. We performed a retrospective cohort study of the medical records of 336 consecutive patients with stage I-I I I CRC who underwent curative resection at a single institution in 2012-2017. Univariate and multivariate analyses were conducted to identify prognostic factors associated with relapse-free survival (RFS) and overall survival (OS). The low CONUT score group exhibited higher RFS and longer OS compared to the high CONUT score group (82.2% vs. 63.3%, p = 0.002 and 95.5% and 86.2%, p = 0.005, respectively). The Akaike's information criterion values of each index for RFS and OS were superior in CONUT score (723.71 and 315.46, respectively) compared to those of PNI (726.95 and 316.52) and mGPS (728.15 and 318.07, respectively). The CONUT score was found to be a good predictor of RFS and OS in patients with resectable CRC.
控制营养状况（CONUT）评分是一种营养标志物，与各种癌症的不良预后相关。然而，目前尚无研究比较使用营养指数评估结直肠癌（CRC）患者复发的风险因素。我们评估了 CONUT 评分与改良格拉斯哥预后评分（mGPS）和预后营养指数（PNI）在 CRC 患者中的预测价值。我们对 2012 年至 2017 年在一家机构接受根治性切除术的 336 例 I 期至 III 期 CRC 患者的病历进行了回顾性队列研究。进行单因素和多因素分析以确定与无复发生存（RFS）和总生存（OS）相关的预后因素。低 CONUT 评分组的 RFS 和 OS 均高于高 CONUT 评分组（82.2% vs. 63.3%，p=0.002 和 95.5%和 86.2%，p=0.005）。对于 RFS 和 OS，每个指数的赤池信息量准则（Akaike's information criterion）值在 CONUT 评分（分别为 723.71 和 315.46）中优于 PNI（分别为 726.95 和 316.52）和 mGPS（分别为 728.15 和 318.07）。CONUT 评分是可切除 CRC 患者 RFS 和 OS 的良好预测指标。
