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高全身炎症反应指数（SIRI）水平作为根治性手术后结直肠癌患者的预后因素：一项单中心回顾性分析

High systemic inflammation response index (SIRI) level as a prognostic factor for colorectal cancer patients after curative surgery: a single-center retrospective analysis.

作者信息

Hayama Tamuro, Ochiai Hiroki, Ozawa Tsuyoshi, Miyata Toshiya, Asako Kentaro, Fukushima Yoshihisa, Kaneko Kensuke, Nozawa Keijiro, Fujii Shoichi, Misawa Takeyuki, Fukagawa Takeo

机构信息

Department of Surgery, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-Ku, Tokyo, 173-8605, Japan.

Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

出版信息

Sci Rep. 2025 Jan 6;15(1):1008. doi: 10.1038/s41598-024-84991-z.

DOI:10.1038/s41598-024-84991-z
PMID:39762444
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11704263/
Abstract

The Systemic Inflammation Response Index (SIRI), a marker used to assess systemic inflammation, is associated with lower patient survival rates in various cancer types. Factors contributing to the recurrence of colorectal cancer (CRC) have been examined previously using the preoperative SIRI. Herein, we investigated the association between the preoperative SIRI level and both the recurrence-free survival (RFS) and overall survival (OS) in patients diagnosed with CRC. We retrospectively analyzed the case of 406 patients who underwent curative surgery for Stage I-III CRC at a single institution during 2012- 2017. Based on their SIRI levels, we categorized the patients into a low-SIRI group (≤ 1700) and a high-SIRI group (> 1700). Multivariable analyses revealed that a high-SIRI level was an independent risk factor for 5-year RFS (p = 0.045) and OS (p = 0.048) in CRC patients. A Kaplan-Meier analysis demonstrated significantly poorer 5-year RFS and OS outcomes in the high-SIRI group compared to the low-SIRI group (p = 0.0001, p = 0.017 respectively). These findings suggest that the high-SIRI level is significantly associated with a poorer prognosis in patients diagnosed with CRC.

摘要

全身炎症反应指数（SIRI）是一种用于评估全身炎症的标志物，与多种癌症类型患者的较低生存率相关。此前已使用术前SIRI对导致结直肠癌（CRC）复发的因素进行了研究。在此，我们调查了术前SIRI水平与CRC确诊患者的无复发生存期（RFS）和总生存期（OS）之间的关联。我们回顾性分析了2012年至2017年期间在一家机构接受I-III期CRC根治性手术的406例患者的病例。根据他们的SIRI水平，我们将患者分为低SIRI组（≤1700）和高SIRI组（>1700）。多变量分析显示，高SIRI水平是CRC患者5年RFS（p = 0.045）和OS（p = 0.048）的独立危险因素。Kaplan-Meier分析表明，与低SIRI组相比，高SIRI组的5年RFS和OS结果明显更差（分别为p = 0.0001，p = 0.017）。这些发现表明，高SIRI水平与CRC确诊患者的较差预后显著相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5eb/11704263/1ddf026843e9/41598_2024_84991_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5eb/11704263/82024857c004/41598_2024_84991_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5eb/11704263/5f7bcde697a4/41598_2024_84991_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5eb/11704263/cf64cd91c4ee/41598_2024_84991_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5eb/11704263/1ddf026843e9/41598_2024_84991_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5eb/11704263/82024857c004/41598_2024_84991_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5eb/11704263/5f7bcde697a4/41598_2024_84991_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5eb/11704263/cf64cd91c4ee/41598_2024_84991_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5eb/11704263/1ddf026843e9/41598_2024_84991_Fig4_HTML.jpg

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本文引用的文献

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Ceramide synthase CERS4 gene downregulation is associated with KRAS mutation in colorectal cancer.CER 合成酶 CERS4 基因下调与结直肠癌中的 KRAS 突变相关。
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Prognostic Value of Exon-specific Mutations in Patients With Colorectal Cancer.
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