Yu Dingle, Zheng Yuejie, Yang Yonghong
Laboratory of Microbiology and Immunology, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing, People's Republic of China.
Department of Respiratory, Shenzhen Children's Hospital, Shenzhen, People's Republic of China.
Infect Drug Resist. 2020 Jul 14;13:2323-2327. doi: 10.2147/IDR.S261975. eCollection 2020.
is regarded as susceptible to β-lactam antibiotics. The guidelines of the Clinical and Laboratory Standards Institute (CLSI) are widely recognized and have long-recommended penicillin for treatment of infections. There is no CLSI guideline for the treatment of infections that have intermediate susceptibility or resistance to penicillin. However, there have been several reports of isolates that are nonsusceptible or even resistant to β-lactam antibiotics, mostly from Chinese journals. The purpose of this commentary is to show data from the literature which suggests the presence of isolates that are not susceptible to β-lactam antibiotics and whether these strains are really nonsusceptible to β-lactam antibiotics and the presence of mutation in the gene requires further research and confirmation.
被认为对β-内酰胺类抗生素敏感。临床和实验室标准协会（CLSI）的指南被广泛认可，长期以来推荐使用青霉素治疗感染。对于对青霉素具有中度敏感性或耐药性的感染，尚无CLSI治疗指南。然而，已有几篇报道称存在对β-内酰胺类抗生素不敏感甚至耐药的分离株，大多来自中文期刊。本评论的目的是展示文献中的数据，这些数据表明存在对β-内酰胺类抗生素不敏感的分离株，以及这些菌株是否真的对β-内酰胺类抗生素不敏感，以及该基因中突变的存在需要进一步研究和证实。
