Department of Oral Biology, Faculty of Dentistry, King AbdulAziz University, Jeddah 80209, Saudi Arabia.
Ibn Sina National College for Medical Studies, Dental College, Jeddah 22421, Saudi Arabia.
ScientificWorldJournal. 2020 Jul 13;2020:7954357. doi: 10.1155/2020/7954357. eCollection 2020.
The electronic databases PubMed and Google Scholar were used to search the literature for relevant studies after applying specific inclusion and exclusion criteria. Studies that fulfilled both the inclusion and exclusion criteria were included in this systematic review. The search was conducted by two independent reviewers following the PRISMA guidelines.
Only 46 studies that fulfilled both the inclusion and exclusion criteria, which were conducted within the last 10 years, were included in this systematic review. These studies investigated different aspects of regenerative endodontic therapy including different types of scaffolds, intracanal medications, pulpal space/barriers, root maturation stage, follow-up duration, and updated studies on their use in the management of immature necrotic permanent teeth.
This review concluded the compiled data observed that endodontic regenerative therapy was more efficient in treating immature necrotic permanent teeth and offered a greater advantage that should lead to wider acceptance among endodontists for effective results compared to different treatment options. However, more clinical trials with a standardized protocol and defined clinical, radiographic, and histopathological outcomes with longer follow-up periods are warranted.
在应用特定的纳入和排除标准后，我们使用电子数据库 PubMed 和 Google Scholar 来搜索相关文献。只有符合纳入和排除标准的研究才被纳入本系统评价。检索由两名独立的审查员按照 PRISMA 指南进行。
本系统评价仅纳入了 46 项符合纳入和排除标准的研究，这些研究都是在过去 10 年内进行的，它们研究了再生性牙髓治疗的不同方面，包括不同类型的支架、根管内药物、牙髓腔/屏障、根尖成熟阶段、随访时间，以及这些方法在处理年轻恒牙根尖周炎中的应用的最新研究。
本综述的综合数据表明，牙髓再生治疗在治疗年轻恒牙根尖周炎方面更有效，并且提供了更大的优势，与不同的治疗选择相比，应该会在牙髓病医生中得到更广泛的接受，以获得有效的结果。然而，需要更多的临床试验，采用标准化方案，并定义临床、放射影像学和组织病理学结果，随访时间更长。
