通过靶向 IGF2BP2，鉴定长链非编码 RNA MIR22HG 作为宫颈癌肿瘤抑制因子的功能特征。
Functional characterization of the long noncoding RNA MIR22HG as a tumour suppressor in cervical cancer by targeting IGF2BP2.
机构信息
Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital, Chongqing, China.
出版信息
Eur Rev Med Pharmacol Sci. 2020 Aug;24(15):7953-7962. doi: 10.26355/eurrev_202008_22478.
OBJECTIVE
Cervical cancer is the most common malignant tumour in the female reproductive tract, ranking second in the global cause of female cancer and seriously endangering women's health. However, the underlying mechanisms leading to cervical cancer are unclear. Previous studies have reported the roles and general underlying mechanisms of the long noncoding RNA MIR22HG (MIR22HG) in multiple types of tumours.
PATIENTS AND METHODS
In this study, we describe the functional role of MIR22HG as a tumour suppressor lincRNA by regulating metastasis, growth and invasion by performing a series of in vivo and in vitro experiments.
RESULTS
Our data suggested that MIR22HG dramatically promoted cervical cancer apoptosis and inhibited invasion by targeting IGF2BP2.
CONCLUSIONS
The long noncoding RNA MIR22HG targets IGF2BP2 as a tumour suppressor in cervical cancer. Our findings will be helpful for developing potential therapeutics for cervical cancer.
目的
宫颈癌是女性生殖道最常见的恶性肿瘤，在全球女性癌症死因中排名第二，严重威胁妇女健康。然而，导致宫颈癌的确切机制尚不清楚。先前的研究报道了长链非编码 RNA MIR22HG（MIR22HG）在多种类型肿瘤中的作用和一般潜在机制。
患者和方法
在本研究中，我们通过一系列体内和体外实验，描述了 MIR22HG 通过调节转移、生长和侵袭作为肿瘤抑制 lincRNA 的功能作用。
结果
我们的数据表明，MIR22HG 通过靶向 IGF2BP2 显著促进宫颈癌细胞凋亡并抑制侵袭。
结论
长链非编码 RNA MIR22HG 作为一种肿瘤抑制因子靶向 IGF2BP2 抑制宫颈癌的发生。我们的研究结果将有助于开发宫颈癌的潜在治疗方法。
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