Clinic Orto MD-Global Care Surgery Hospital, Novi Sad, Serbia.
Eur Rev Med Pharmacol Sci. 2020 Aug;24(15):8075-8080. doi: 10.26355/eurrev_202008_22491.
Autism Spectrum Disorder is a complex brain disorder and has multiple causes that occur in diverse combinations. There is a need to classify children with ASD at a very young age so that they can access evidence-based intervention that can significantly improve their outcomes.
In this report we present a case of autism, which underwent intrathecal autologous bone marrow mononuclear cells transplantation along with neurorehabilitation. The primary goal of the treatment is to improve the quality of life of the patient. After the procedure, the child started to speak, therefore, the third communication subscale was scored within the GARS-2 assessment instrument. With these three subscales, a score of 91 has been achieved, representing an autism index of 27%, a significant improvement over the previous score.
Our study demonstrated evidences to support the safety and effectiveness of BMAC transplantation in the management of autism.
自闭症谱系障碍是一种复杂的脑部疾病，有多种病因，并以不同组合形式出现。因此，需要在患儿很小的时候对其进行分类，以便他们能够接受循证干预，从而显著改善他们的预后。
本报告介绍了一例自闭症病例，该患儿接受了鞘内自体骨髓单个核细胞移植联合神经康复治疗。治疗的主要目标是提高患者的生活质量。治疗后，患儿开始说话，因此，在 GARS-2 评估工具中对第三个沟通分量表进行了评分。使用这三个分量表，患儿获得了 91 分，自闭症指数为 27%，相较于之前的评分有显著提高。
我们的研究提供了证据支持 BMAC 移植在自闭症管理中的安全性和有效性。
