Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA, 02139, USA.
Angew Chem Int Ed Engl. 2020 Nov 16;59(47):20890-20894. doi: 10.1002/anie.202009819. Epub 2020 Sep 11.
Electroorganic synthesis is a promising tool to design sustainable transformations and discover new reactivities. However, the added setup complexity caused by electrodes in the system impedes efficient screening of reaction conditions. Herein, we present a microfluidic platform that enables automated high-throughput experimentation (HTE) for electroorganic synthesis at a 15-microliter scale. Two HTE modules are demonstrated: 1) the rapid electrochemical reaction condition screening for a radical-radical cross-coupling reaction on micro-fabricated interdigitated electrodes, and 2) measurements of kinetics for mediated anodic oxidations using the microliter-scale cyclic voltammetry. The presented modular approach could be deployed for a range of other electroorganic chemistry applications beyond the demonstrated functionalities.
电有机合成是一种很有前途的工具，可以设计可持续的转化和发现新的反应性。然而，系统中电极带来的附加设置复杂性阻碍了反应条件的有效筛选。在此，我们提出了一种微流控平台，可在 15 微升规模上实现电有机合成的自动化高通量实验（HTE）。展示了两个 HTE 模块：1）在微制造的叉指电极上进行自由基-自由基交叉偶联反应的快速电化学反应条件筛选，2）使用微升规模循环伏安法测量介导阳极氧化的动力学。所提出的模块化方法可应用于除所展示功能之外的一系列其他电有机化学应用。
