维生素 E 天然类似物综述及合成维生素 E 衍生物作为细胞保护剂的设计。

A Review on Vitamin E Natural Analogues and on the Design of Synthetic Vitamin E Derivatives as Cytoprotective Agents.

机构信息

Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki 54124, Greece.

出版信息

Mini Rev Med Chem. 2021;21(1):10-22. doi: 10.2174/1389557520666200807132617.

DOI:10.2174/1389557520666200807132617

PMID:32767937

Abstract

Vitamin E, essential for human health, is widely used worldwide for therapeutic or dietary reasons. The differences in the metabolism and excretion of the multiple vitamin E forms are presented in this review. The important steps that influence the kinetics of each form and the distribution and processing of vitamin E forms by the liver are considered. The antioxidant as well as non-antioxidant properties of vitamin E forms are discussed. Finally, synthetic tocopherol and trolox derivatives, based on the design of multitarget directed compounds, are reviewed. It is demonstrated that selected derivatization of vitamin E or trolox structures can produce improved antioxidants, agents against cancer, cardiovascular and neurodegenerative disorders.

摘要

维生素 E 对人类健康至关重要，目前在世界范围内广泛应用于治疗和饮食目的。本综述介绍了多种维生素 E 形式的代谢和排泄差异。文中还考虑了影响每种形式动力学以及肝脏对维生素 E 形式分配和加工的重要步骤。讨论了维生素 E 形式的抗氧化和非抗氧化特性。最后，还综述了基于多靶点导向化合物设计的合成生育酚和 Trolox 衍生物。结果表明，对维生素 E 或 Trolox 结构的选择性衍生化可以产生更好的抗氧化剂，用于治疗癌症、心血管和神经退行性疾病。