Department of Biochemistry, Cell Culture & Molecular Biology Lab, Sri Venkateswara University, Tirupati, India.
Endocr Metab Immune Disord Drug Targets. 2021;21(2):246-252. doi: 10.2174/1871530320666200807115647.
Scientific research continues to develop more efficacious drugs to treat and cure cancer, the dreadful disease threatening the human race. Chemotherapy is an essential means in cancer therapy, however, plant drugs having pharmacological safety, can be used alone or as additions to current chemotherapeutic agents to enhance therapeutic efficacy and minimize chemotherapyinduced adverse effects.
A combination therapy where the synergistic effect on multiple targets is possible has gained significance because a one-drug one-target approach fails to yield the desired therapeutic effect. Therefore, a detailed description of important plant polyphenolic compounds with anticancer activity and their role in potentiating chemotherapeutic efficiency of existing anticancer drugs is provided in this review. Systematically screening combinations of active pharmaceutical ingredients for potential synergy with plant compounds may be especially valuable in cancer therapy.
We extensively have gone through reviews and research articles available in the literature. We made use of databases such as Google Scholar, Research Gate, PubMed, Science Direct, etc. The following keywords were used in our literature search: "Chemotherapy, drug development, cancer drugs, plant-derived polyphenolics, synergistic studies, combination therapy, diagnosis and genetics."
Systematic research studies on screening combinations of plant phytochemicals with potential chemotherapeutic pharmaceuticals shed light on their synergistic effects, mechanisms of actions paving the way to develop more efficient anticancer therapeutics to treat and cure the cancer menace, to nullify chemotherapy-induced adverse effects and our review substantially contributes in this direction.
科学研究不断开发更有效的药物来治疗和治愈癌症，这种可怕的疾病威胁着人类。化疗是癌症治疗的重要手段，然而，植物药物具有药理安全性，可以单独使用或作为现有化疗药物的补充，以提高治疗效果并最小化化疗引起的不良反应。
由于一种药物一种靶点的方法无法产生所需的治疗效果，因此具有多靶点协同作用的联合治疗变得尤为重要。因此，本综述详细描述了具有抗癌活性的重要植物多酚化合物及其在增强现有抗癌药物化疗效果中的作用。系统筛选活性药物成分与植物化合物的潜在协同作用可能在癌症治疗中特别有价值。
我们广泛查阅了文献中的综述和研究文章。我们利用了 Google Scholar、Research Gate、PubMed、Science Direct 等数据库。我们在文献检索中使用了以下关键词：“化疗、药物开发、癌症药物、植物来源的多酚、协同研究、联合治疗、诊断和遗传学”。
对植物植物化学物质与潜在化疗药物的组合进行系统研究，揭示了它们的协同作用，作用机制为开发更有效的抗癌疗法来治疗和治愈癌症威胁、消除化疗引起的不良反应铺平了道路，我们的综述在这方面做出了重要贡献。
