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铁死亡在蒽环类化疗中的双重作用包括降低耐药性和增加毒性。

The dual role of ferroptosis in anthracycline-based chemotherapy includes reducing resistance and increasing toxicity.

作者信息

Zhao Jiazheng, Zhang Ning, Ma Xiaowei, Li Ming, Feng Helin

机构信息

Department of Orthopedics, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, Hebei, 050011, China.

Department of Cardiology, The Fourth Hospital of Hebei Medical University, 12 Health Road, Shijiazhuang, Hebei, 050011, China.

出版信息

Cell Death Discov. 2023 Jun 21;9(1):184. doi: 10.1038/s41420-023-01483-1.

DOI:10.1038/s41420-023-01483-1
PMID:37344500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10284859/
Abstract

In conjunction with previous studies, we have noted that ferroptosis, as an emerging mode of regulated cell death (RCD), is intimately related to anthracycline pharmacotherapy. Not only does ferroptosis significantly modulate tumour resistance and drug toxicity, which are core links of the relevant chemotherapeutic process, but it also appears to play a conflicting role that has yet to be appreciated. By targeting the dual role of ferroptosis in anthracycline-based chemotherapy, this review aims to focus on the latest findings at this stage, identify the potential associations and provide novel perspectives for subsequent research directions and therapeutic strategies.

摘要

结合先前的研究，我们注意到铁死亡作为一种新出现的调节性细胞死亡（RCD）模式，与蒽环类药物治疗密切相关。铁死亡不仅显著调节肿瘤耐药性和药物毒性，而这是相关化疗过程的核心环节，而且它似乎还发挥着一种尚未被认识到的矛盾作用。通过针对铁死亡在蒽环类药物化疗中的双重作用，本综述旨在聚焦现阶段的最新研究结果，确定潜在的关联，并为后续的研究方向和治疗策略提供新的视角。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0f/10284859/01d16ce0c5bb/41420_2023_1483_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0f/10284859/0366ee9c6d48/41420_2023_1483_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0f/10284859/77b1b4834742/41420_2023_1483_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0f/10284859/cd2352f039ee/41420_2023_1483_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0f/10284859/01d16ce0c5bb/41420_2023_1483_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0f/10284859/0366ee9c6d48/41420_2023_1483_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0f/10284859/77b1b4834742/41420_2023_1483_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0f/10284859/cd2352f039ee/41420_2023_1483_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e0f/10284859/01d16ce0c5bb/41420_2023_1483_Fig4_HTML.jpg

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