Department of Chemistry and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, United States.
Department of Chemistry and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, United States.
Curr Opin Chem Biol. 2020 Aug;57:114-121. doi: 10.1016/j.cbpa.2020.06.008. Epub 2020 Aug 5.
Acoustic-based imaging modalities (e.g. ultrasonography and photoacoustic imaging) have emerged as powerful approaches to noninvasively visualize the interior of the body due to their biocompatibility and the ease of sound transmission in tissue. These technologies have recently been augmented with an array of chemical tools that enable the study and modulation of the tumor microenvironment at the molecular level. In addition, the application of ultrasound and ultrasound-responsive materials has been used for drug delivery with high spatiotemporal control. In this review, we highlight recent advances (in the last 2-3 years) in acoustic-based chemical tools and technologies suitable for furthering our understanding of molecular events in complex tumor microenvironments.
基于声学的成像模式（例如超声和光声成像）由于其生物相容性和在组织中声音传输的容易性，已成为无创可视化体内内部的强大方法。这些技术最近通过一系列化学工具得到了增强，这些工具可以在分子水平上研究和调节肿瘤微环境。此外，超声和超声响应材料的应用已用于具有高时空控制的药物输送。在这篇综述中，我们强调了过去 2-3 年来基于声学的化学工具和技术的最新进展，这些进展适合进一步了解复杂肿瘤微环境中的分子事件。
