miR-4293 rs12220909多态性与癌症风险的关联：对8394名受试者的荟萃分析
Association of miR-4293 rs12220909 polymorphism with cancer risk: A meta-analysis of 8394 subjects.
作者信息
Liu Rongqiang, Fu Hongyuan, Yu Yajie, Xu Qianhui, Fang Jiangwen, Ge Qianmin, Shao Yi
机构信息
Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi.
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong.
出版信息
Medicine (Baltimore). 2020 Aug 7;99(32):e21364. doi: 10.1097/MD.0000000000021364.
BACKGROUND
Several studies have investigated miR-4293 rs12220909 polymorphisms and cancer susceptibility and yielded different results. Because of this controversy, we designed a meta-analysis to assess comprehensively the association of the rs12220909 polymorphism with cancer risk.
METHODS
Relevant articles were collected by searching the databases of PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and WanFang. Data on rs12220909 in cancer patients and controls were extracted. Sensitivity analyses and publication bias assessments were performed.
RESULTS
Five studies with 3820 cases and 4574 controls were included in our meta-analysis. Pooled analyses showed that the rs12220909 polymorphism was not associated with cancer risk in any genetic model. (C vs G: odds ratio [OR] = 0.89, 95% confidence interval [CI] = 0.74-1.07; GC vs GG: OR = 0.83, 95% CI = 0.67-1.03; CC vs GG: OR = 1.06, 95% CI = 0.82-1.36; CC+GC vs GG: OR = 0.84, 95% CI = 0.69-1.03; CC vs GC+GG: OR = 1.10, 95% CI = 0.85-1.40).
CONCLUSIONS
Our results indicate that rs12220909 is not associated with cancer risk. Larger, well-designed multicenter studies are needed to further explore the association of miR-4293 rs12220909 polymorphism with cancer risk.
背景
多项研究调查了miR - 4293 rs12220909多态性与癌症易感性的关系，但结果各异。鉴于这种争议，我们设计了一项荟萃分析，以全面评估rs12220909多态性与癌症风险的关联。
方法
通过检索PubMed、Embase、Web of Science、中国知网（CNKI）和万方数据库收集相关文章。提取癌症患者和对照组中rs12220909的数据。进行敏感性分析和发表偏倚评估。
结果
我们的荟萃分析纳入了5项研究，共3820例病例和4574例对照。汇总分析表明，在任何遗传模型中，rs12220909多态性均与癌症风险无关。（C与G比较：比值比[OR]=0.89，95%置信区间[CI]=0.74 - 1.07；GC与GG比较：OR=0.83，95% CI=0.67 - 1.03；CC与GG比较：OR=1.06，95% CI=0.82 - 1.36；CC + GC与GG比较：OR=0.84，95% CI=0.69 - 1.03；CC与GC + GG比较：OR=1.10，95% CI=0.85 - 1.40）。
结论
我们的结果表明，rs12220909与癌症风险无关。需要开展更大规模、设计良好的多中心研究，以进一步探索miR - 4293 rs12220909多态性与癌症风险的关联。
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