Curriculum in Toxicology & Environmental Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Center for Environmental Medicine, Asthma, and Lung Biology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Curr Allergy Asthma Rep. 2020 Aug 8;20(10):62. doi: 10.1007/s11882-020-00952-2.
The purpose of this review is to integrate recent research on the respiratory immune effects of e-cigarettes with the pathogenesis of asthma to better understand how e-cigarettes may affect asthmatics and to note critical knowledge gaps regarding the effects of e-cigarettes on asthmatics.
Human, rodent, and cell culture studies show that key cellular functions of epithelial cells, macrophages, and neutrophils are altered by e-cigarette exposure. Because respiratory immunity is already dysregulated in asthma, further alteration of cellular function by e-cigarettes could impact asthma development, severity, and/or exacerbations. Future research is needed to more directly investigate this relationship using controlled human exposure studies and exposure of cell culture or animal models of asthma to e-cigarettes.
本综述的目的是将电子烟对呼吸系统免疫的影响的最新研究与哮喘发病机制相结合，以更好地了解电子烟可能如何影响哮喘患者，并注意到关于电子烟对哮喘患者影响的关键知识空白。
人体、啮齿动物和细胞培养研究表明，上皮细胞、巨噬细胞和中性粒细胞的关键细胞功能因电子烟暴露而改变。由于哮喘患者的呼吸免疫已经失调，电子烟进一步改变细胞功能可能会影响哮喘的发展、严重程度和/或恶化。需要进一步的研究，使用对照人体暴露研究和哮喘细胞培养或动物模型暴露于电子烟来更直接地调查这种关系。
