Department of Dermatology, Venereology, and Andrology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Department of Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Lasers Surg Med. 2021 Apr;53(4):458-467. doi: 10.1002/lsm.23306. Epub 2020 Aug 8.
To compare the efficacy of autologous platelet-rich plasma (PRP), ablative fractional carbon dioxide (FCO ) laser, and their combination in the treatment of atrophic acne scars, both clinically and immuno-histopathologically.
STUDY DESIGN/MATERIALS AND METHODS: Sixty patients were randomly divided into three equal groups. Group 1 received intradermal PRP injection sessions. Group 2 received FCO laser sessions. Group 3 received FCO laser followed by intradermal PRP injection sessions. Each group received three sessions at monthly intervals. The final assessment took place 3 months after the last session. Skin biopsies were obtained before and 1 month after treatment sessions with pathological evaluation.
Combined PRP and FCO laser-treated patients had a better clinical response, fewer side effects, and shorter downtime than FCO laser alone. PRP-treated patients had some improvement but significantly lower than the other two groups.
The current study concluded that a combination of PRP and FCO laser is an effective and safe modality in the treatment of atrophic acne scars with better results than PRP or FCO laser alone. Lasers Surg. Med. © 2020 Wiley Periodicals LLC.
比较富血小板血浆（PRP）、消融性二氧化碳（FCO）激光及其联合治疗萎缩性痤疮瘢痕的临床和免疫组织病理学疗效。
研究设计/材料和方法：将 60 名患者随机分为三组。第 1 组接受皮内 PRP 注射治疗。第 2 组接受 FCO 激光治疗。第 3 组先接受 FCO 激光治疗，然后接受皮内 PRP 注射治疗。每组每月接受 3 次治疗。末次治疗后 3 个月进行最终评估。在治疗前后 1 个月进行皮肤活检，进行病理评估。
联合 PRP 和 FCO 激光治疗的患者比单独接受 FCO 激光治疗的患者有更好的临床反应、更少的副作用和更短的停机时间。PRP 治疗的患者有一些改善，但明显低于其他两组。
本研究表明，PRP 和 FCO 激光联合治疗是治疗萎缩性痤疮瘢痕的一种有效且安全的方法，其疗效优于 PRP 或 FCO 激光单独治疗。激光外科医学杂志。2020 年 Wiley 期刊 LLC 出版。
